2,4-Dichloro-6-methylpyrimidine

2,4-Dichloro-6-methylpyrimidine Basic information

Product Name:	2,4-Dichloro-6-methylpyrimidine
Synonyms:	AKOS BBS-00005839;2,6-DICHLORO-4-METHYLPYRIMIDINE;2,4-DICHLORO-6-METHYLPYRIMIDINE;2,4-dichloro-6-methyl-pyrimidin;2,4-DICHLORO-6-METHYLPYRIMIDE;2,4-Dichloro-6-methylpyrimidine ,99%;2,4-Dichloro-6-methylpyrimidine,98%;4-Dichloro-6-MethylpyriMidine
CAS:	5424-21-5
MF:	C5H4Cl2N2
MW:	163
EINECS:	226-563-4
Product Categories:	Heterocycle-Pyrimidine series;Building Blocks;C4 to C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Compounds;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building Blocks;Pyrimidine Series;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Pyrimidine;Pyrimidines
Mol File:	5424-21-5.mol

2,4-Dichloro-6-methylpyrimidine Chemical Properties

Melting point	44-47 °C (lit.)
Boiling point	219 °C (lit.)
density	1.5462 (rough estimate)
refractive index	1.6300 (estimate)
Fp	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Very Slightly, Heated, Sonicated), DMSO (Sparingly, Heated)
form	powder to crystal
pka	-2.12±0.30(Predicted)
color	White to Orange to Green
Water Solubility	Soluble in Chloroform, Ether, Ethyl Acetate and Toluene. Insoluble in water.
BRN	114295
CAS DataBase Reference	5424-21-5(CAS DataBase Reference)
EPA Substance Registry System	Pyrimidine, 2,4-dichloro-6-methyl- (5424-21-5)

Safety Information

MSDS Information

2,4-Dichloro-6-methylpyrimidine Usage And Synthesis

Chemical Properties	White to Light Yellow Powder
Uses	2,4-Dichloro-6-methylpyrimidine is used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine.
General Description	2,4-Dichloro-6-methylpyrimidine undergoes double cross-coupling reaction with 2-(tributylstannyl)pyridine, followed by aldol condensation to yield 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines. It reacts with 1H,1H,2H,2H-perfluorodecanethiol during fluorous synthesis of disubstituted pyrimidines.

2,4-Dichloro-6-methylpyrimidine Preparation Products And Raw materials

Raw materials	2-Pyrimidinamine, 4-chloro-N,N-diethyl-6-methyl--->2-Pyrimidinamine, 4-chloro-N,6-dimethyl-N-phenyl--->2-chloro-N,6-dimethyl-N-phenylpyrimidin-4-amine-->4(3H)-PYRIMIDINONE, 5-BROMO-6-METHYL-2-(METHYLTHIO)--->6-Methyl-2-(methylthio)pyrimidin-4-ol-->5-Bromo-2,4-dichloro-6-methylpyrimidine-->5-BROMO-6-METHYLURACIL-->Tributylamine-->6-Methyluracil
Preparation Products	6-METHYL-2-(METHYLSULFANYL)PYRIMIDIN-4-YLAMINE-->CRIMIDINE-->4-AMINO-6-METHYLPYRIMIDINE-2-THIOL-->2-AMINO-6-METHYL-PYRIMIDINE-4-THIOL-->2-Chloro-6-methylpyrimidin-4-ylamine-->2-CHLORO-6-METHYLPYRIMIDIN-4-AMINE

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