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| Product Name: | Fusidine | | Synonyms: | 4-alpha,8-alpha,9-beta,11-alpha,13-alpha,14-beta,16-beta,17z)-ph;ramycin;sq16603;(3ALPHA,4ALPHA,8ALPHA,9BETA,11ALPHA,13ALPHA,14BETA,16BETA,17Z)-16-(ACETYLOXY)-3,11-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID;FUSIDIC ACID;29-NordaMMara-17(20),24-dien-21-oicacid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-;Fusidic acid for peak identification;Fusidic acid, 98.5% | | CAS: | 6990-06-3 | | MF: | C31H48O6 | | MW: | 516.72 | | EINECS: | 230-256-0 | | Product Categories: | Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API;FUCIDINE;antibiotic;Steroids;E-FCell Signaling and Neuroscience;Gene Regulation and Expression;RNA-Protein Translation Inhibitors;Stains and Dyes;Stains&Dyes, A to;6990-06-3 | | Mol File: | 6990-06-3.mol |  |
| | Fusidine Chemical Properties |
| Melting point | 190-192°C | | alpha | D20 -9° (chloroform) | | Boiling point | 521.49°C (rough estimate) | | density | 1.0389 (rough estimate) | | vapor pressure | 0-0Pa at 25℃ | | refractive index | 1.4890 (estimate) | | storage temp. | Sealed in dry,2-8°C | | solubility | Practically insoluble in water, freely soluble in ethanol (96 per cent) | | form | neat | | pka | pK: 5.35 in water | | color | White to Off-White | | Water Solubility | 2.376-525000μg/L at 25℃ | | λmax | 204nm(H2O)(lit.) | | Merck | 14,4317 | | Stability: | Hygroscopic | | LogP | 2.68-6.75 at 20℃ | | CAS DataBase Reference | 6990-06-3(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | RC1350000 | | HS Code | 29419000 | | Toxicity | LD50 in mice (g/kg): 1.2 s.c.; 1.5 orally (Godtfredsen) |
| | Fusidine Usage And Synthesis |
| Mode of action | Fusidic acid forms a stable complex with an elongation factor (EF-G) involved in translocation and with guanosine triphosphate (GTP), which provides energy for the translocation process. One round of translocation occurs, with hydrolysis of GTP, but the fusidic acid–EF-G–GDP complex cannot dissociate from the ribosome, thereby blocking further chain elongation and leaving peptidyl-tRNA in the P site.
Although protein synthesis in Gram-negative bacilli–and, indeed, mammalian cells–is susceptible to fusidic acid, the antibiotic penetrates poorly into these cells and the spectrum of action is virtually restricted to Gram-positive bacteria, notably staphylococci.
| | Chemical Properties | White Solid | | Uses | antibacterial | | Uses | Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites. | | Definition | ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum. | | Brand name | Fucidine (Bristol-Myers Squibb). | | Hazard | Moderately toxic inhibitor of translocation
during protein synthesis. | | Biochem/physiol Actions | Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections. |
| | Fusidine Preparation Products And Raw materials |
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