Bleomycin sulfate

Bleomycin sulfate Basic information
Product Name:Bleomycin sulfate
Synonyms:Bleomycin sulfate, 1.5-2.0 units/mg;BLEOMYCIN SULFATE, BPC;BLEOMYCIN SULFATE FROM STREPTOMYCES VERT ICILLUS, LYOPH.;BLEOMYCIN SULFATE FROM STREPTOMYCES VERTICILLUS 0 TO 5 °C;Blocamicina;BLEMOYCIN SULFATE;3-[[2-[2-[2-[2-[4-[2-[6-Amino-2-[1-(2-amino-2-carbamoyl-ethyl)amino-2-carbamoyl-ethyl]-5-methyl-pyrimidin-4-yl]carbonylamino-3-[3-[4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(3H-imidazol-4-yl)propanoyl]amino-3-hydroxy-2-methyl-pentanoyl]amino-3-hydroxy-butanoyl]aminoethyl]-1,3-thiazol-4-yl]-1,3-thiazol-4-yl]carbonylamino]propyl-dimethyl-sulfonium hydrogen sulfate;Bleomycin Sulfate, Blenoxane
CAS:9041-93-4
MF:C110H168N34O46S7
MW:2927.17
EINECS:232-925-2
Product Categories:BLENOXANE;antibiotic;Intermediates & Fine Chemicals;Pharmaceuticals;Carbohydrates & Derivatives;Sulfur & Selenium Compounds;Active Pharmaceutical Ingredients;UVCBs-biological;API;Inhibitors
Mol File:9041-93-4.mol
Bleomycin sulfate Structure
Bleomycin sulfate Chemical Properties
Melting point 200-204°C (dec.)
storage temp. 2-8°C
solubility H2O: 20 mg/mL
form powder
color white
Water Solubility Soluble in water or DMSO
Merck 14,1318
Stability:Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference9041-93-4(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi
Risk Statements 46-40-36/37/38-63
Safety Statements 53-36/37-45-36-26
WGK Germany 3
RTECS EC5991990
10
HS Code 2941906000
MSDS Information
ProviderLanguage
SigmaAldrich English
Bleomycin sulfate Usage And Synthesis
DescriptionBleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1?and RNA2. Induces double-strand DNA damage.3?Commonly used to induce lung fibrosis in animal disease models.4,5?Anticancer agent in clinical use.6
Chemical PropertiesWhite Powder
UsesBleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at less and more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.
UsesBleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.
UsesBleomycin is a complex of 11 glycopeptide antitumour antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight . Bleomycins have found clinical application in the treatment of a range of tumours. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.
UsesA group of related glycopeptide antibiotics. Bleomycin A2 is the main component of the bleomycin employed clinically. Antineoplastic
Brand nameBlenoxane (Bristol-Myers Squibb).
General DescriptionBleomycin occurs as a white powder and is available in 15-and 30-U vials for reconstitution in water. It may be givenintravenously, intramuscularly, or subcutaneously. It is used in the treatment of squamous cell carcinoma of the headneck, cervix, penis, and vulva. It is also used in Hodgkin’sand non-Hodgkin’s lymphoma as well as testicular carcinoma.Unlabeled uses include the treatment of mycosis fungoides,osteosarcoma, and AIDS-related Kaposi sarcoma.
Biochem/physiol ActionsBleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.
Clinical UseBleomycin is used IV in the palliative treatment of squamous cell head and neck cancers, testicular and other genital carcinomas, and Hodgkin's and non-Hodgkin's lymphoma.
Side effectsIt is excreted via the kidneys, and serum concentrations of active drug are increased in patients with renal disease. The elimination half-life can rise from 2 to 4 hours to more than 20 hours in renal failure, resulting in significant toxicity, especially pulmonary toxicity.
Veterinary Drugs and TreatmentsBleomycin has occasionally been used as adjunctive treatment of lymphomas, squamous cell carcinomas, teratomas, and nonfunctional thyroid tumors in both dogs and cats. Recent work has demonstrated that bleomycin may be promising for intralesional treatment for a variety of localized tumors with or without concomitant electropermeabilization.
targetUT-SCC-129 cells
References1) Petering?et al.?(1990),?The role of redox-active metals in the mechanism of action of bleomycin; Chem. Biol. Interact.,?73?133 2) Huttenhofer?et al. (1992),?Cleavage of tRNA by Fe(II)-bleomycin; J. Biol. Chem.,?267?24471 3) Lee?et al.?(2017)?ASF1a Promotes Non-homologous End Joining Repair by facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks;?Mol. Cell?68?61 4)?Xie?et al.?(2016), Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis; Respir. Res.,?17?103 5) Inomata?et al. (2014) Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis; Respir. Res.,?15?16 6) Tanaka?et al. (2008)?Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells; Anticancer Res.,?28?2663
Neomycin sulfate Heparitin, sulfate Ethanol sulfate ALTRENOGEST BLEOMYCIN SULFATE, STREPTOMYCES VERTICILLUS Ethyl acetate Ethyl vanillin Sodium thiosulfate pentahydrate Ferrous sulfate monohydrate calcium sulfate Colistin sulfate Ethyl acrylate Bleomycin sulfate BLEOMYCIN SULFATE (15 UNITS) Ferrous sulfate heptahydrate Ethyl 4'-hydroxy-3'-methoxycinnamate Magnesium sulfate heptahydrate

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.