Teprenone

Teprenone Basic information
Product Name:Teprenone
Synonyms:All trans-Teprenone;(5Z,9Z,13Z)-6,10,14,18-tetramethyl-2-nonadeca-5,9,13,17-tetraenone;6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one;TEPRENONE;13,17-nonadecatetraen-2-one,6,10,14,18-tetramethyl-9;geranylgeranylacetone;6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetren-2-one;Selbex
CAS:6809-52-5
MF:C23H38O
MW:330.55
EINECS:614-276-0
Product Categories:Aliphatics;Intermediates & Fine Chemicals;Pharmaceuticals;6809-52-5
Mol File:6809-52-5.mol
Teprenone Structure
Teprenone Chemical Properties
Boiling point bp0.01 155-160°
density d420.5 0.9081
refractive index nD20 1.4947
storage temp. -20°C
solubility DMSO: >5mg/mL
form liquid
color clear
Merck 14,9228
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKeySBOCYPUKNYDTSX-DMLVRTFPSA-N
LogP8.200 (est)
CAS DataBase Reference6809-52-5(CAS DataBase Reference)
Safety Information
WGK Germany 3
RTECS RA5391300
HS Code 2914.19.0000
MSDS Information
Teprenone Usage And Synthesis
DescriptionTeprenone (geranylgeranylacetone) is an antiulcer agent whose synthesis was inspired by the gastric protecting properties of Coenzyme Q10. Teprenone is reported to act via enhancement of gastric mucosal glycoprotein secretion.
DescriptionGeranylgeranylacetone is an inducer of heat shock protein (Hsp) expression that has been shown to increase Hsp70 (also known as Hsp72 and HspA1A), Hsp22 (HspB8), Hsp27 (HspB1), Hsp90 (HspC), and Hsp105 (HspH1) levels in various cells and tissues. It is orally bioavailable and has diverse effects in vivo, including hepatoprotective, neuroprotective, and antiulcerative effects. The effects of geranylgeranylacetone on Hsp expression are more pronounced under stress conditions.
Chemical PropertiesYellow Oil
OriginatorEisai (Japan)
UsesAn anti-ulcerative. Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.
UsesGeranylgeranylacetone has been used as an inducer of heat shock protein 70 (HSP70) to analyze its protective effects against cerebral ischemia/reperfusion (I/R).
DefinitionChEBI: A terpene ketone in which a (9E,13E)-geranylgernayl group is bonded to one of the alpha-methyls of acetone (it is a mixture of 5E- and 5Z-geoisomers in a 3:2 ratio).
Brand nameSELBEX
Biochem/physiol ActionsGeranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.
References1) Kamal and Omran (2013) The role of heat shock protein 70 induced by geranylgeranylacetone in carbon tetrachloride-exposed adult rat testes; Pathophysiology, 20 139 2) Lennikov et al. (2013) Induction of heat chock protein 70 ameliorates ultraviolet-induced photokeratitis in mice; Int. J. Mol. Sci., 14 2175 3) Adache et al. (2010) An acyclic polyisoprenoid derivative, geranylgeranylacetone, protects against visceral adiposity and insulin resistance in high fat fed mice; Am. J. Physiol. Endocrinol. Metab., 299 E764 4) Marunouchi et al. (2014) Protective effect of geranylgeranylacetone via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats; Eur. J. Pharmacol. 730 140
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