ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives BOC-amino acid Boc-5-aminopentanoic acid

Boc-5-aminopentanoic acid

Boc-5-aminopentanoic acid Basic information
Product Name:Boc-5-aminopentanoic acid
Synonyms:N-T-BUTOXYCARBONYL-5-AMINOPENTANOIC ACID;N-DELTA-T-BUTOXYCARBONYL-DELTA-AMINOVALERIC ACID;N-BOC-5-AMINOPENTANOIC ACID;N-BOC-5-AMINOVALERIC ACID;PENTANOIC ACID, 5-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-;RARECHEM EM WB 0073;5-(TERT-BUTOXYCARBONYLAMINO)VALERIC ACID;5-(TERT-BUTOXYCARBONYLAMINO)PENTANOIC ACID
CAS:27219-07-4
MF:C10H19NO4
MW:217.26
EINECS:
Product Categories:
Mol File:27219-07-4.mol
Boc-5-aminopentanoic acid Structure
Boc-5-aminopentanoic acid Chemical Properties
Melting point 48-52 °C(lit.)
Boiling point 160-168 °C0.8 mm Hg(lit.)
density 1.1518 (rough estimate)
refractive index 1.4500 (estimate)
Fp >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
pka4.72±0.10(Predicted)
form Powder
color Off-white
BRN 2048862
CAS DataBase Reference27219-07-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
F 10-21
HazardClass IRRITANT
HS Code 29241990
MSDS Information
ProviderLanguage
SigmaAldrich English
Boc-5-aminopentanoic acid Usage And Synthesis
DescriptionBoc-5-aminopentanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. Boc-5-aminopentanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Propertiessolid
UsesBoc-5-aminovaleric acid can be used to synthesize inhibitors of bacterial quorum seining and biofilm formation. It can also be used to synthesize diblock and triblock copolymers.
Synthesis Reference(s)The Journal of Organic Chemistry, 48, p. 2424, 1983 DOI: 10.1021/jo00162a028
Estradiol valerate MAGNESIUM DIPROPYLACETATE HYDRATE Ethyl 2-(Chlorosulfonyl)acetate Nalpha-Fmoc-Ndelta-Boc-L-ornithine BOC-D-PRO-OSU Z-D-ORN(BOC)-OH ALTRENOGEST Folic acid Glycine BOC-PRO-ONP BOC-HYP-OBZL 2-Propylpentanoic acid Z-ORN(BOC)-OH phosphoric acid Boc-5-aminopentanoic acid BOC-HYP-OH DCHA AMINO ACIDS 5-AMINOVALERIC ACID
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