4-(Trifluoromethyl)phenylacetic acid

4-(Trifluoromethyl)phenylacetic acid Basic information

Product Name:	4-(Trifluoromethyl)phenylacetic acid
Synonyms:	(alpha,alpha,alpha-trifluoro-4-tolyl)acetic acid;(α,α,α-Trifluoro-p-tolyl)acetic acid;4-(Trifluoromethyl)Phenylaceti;(à,à,à-trifluoro-p-tolyl)acetic acid;4-(Trifluoromethyl)phenylacetic acid 98%;4-(Trifluoromethyl)phenylaceticacid98%;(A,A,A-TRIFLUORO-P-TOLY)ACETIC ACID;4-(Trifluoromethyl)benzeneacetic acid
CAS:	32857-62-8
MF:	C9H7F3O2
MW:	204.15
EINECS:	251-263-5
Product Categories:	Aromatic Phenylacetic Acids and Derivatives;Phenylacetic acid;Acids and Derivatives;Pyridines ,Heterocyclic Acids
Mol File:	32857-62-8.mol

4-(Trifluoromethyl)phenylacetic acid Chemical Properties

Melting point	82-85 °C(lit.)
Boiling point	203°C (rough estimate)
density	1.2815 (estimate)
storage temp.	Sealed in dry,Room Temperature
pka	4.01±0.10(Predicted)
form	Crystals or Crystalline Powder
color	White to very pale yellow
BRN	2267687
CAS DataBase Reference	32857-62-8(CAS DataBase Reference)
NIST Chemistry Reference	(«ALPHA»,«alpha»,«alpha»-trifluoro-p-tolyl)-acetic acid(32857-62-8)

Safety Information

MSDS Information

4-(Trifluoromethyl)phenylacetic acid Usage And Synthesis

Chemical Properties	white to very pale yellow crystals or
Uses	4-(Trifluoromethyl)benzeneacetic Acid is an intermediate used to synthesize PPARγ/δ dual agonists via solid-Phase parallel synthesis. It was also used to prepare heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.
General Description	4-(Trifluoromethyl)phenylacetic acid undergoes diolefination mediated by mono-N-protected amino acid ligands in the presence of ethyl acrylate, Pd(OAc)₂, KHCO₃ and t-amyl alcohol.

4-(Trifluoromethyl)phenylacetic acid Preparation Products And Raw materials

Raw materials	Ethanol-->Sodium hydroxide-->Ethyl acetate-->Tetrahydrofuran-->Dichloromethane-->PETROLEUM ETHER-->Magnesium-->4-(Trifluoromethoxy)benzyl bromide
Preparation Products	2-NITRO-4-(TRIFLUOROMETHYL)PHENYLACETIC ACID-->1-[4-(TRIFLUOROMETHYL)PHENYL]BUTAN-2-ONE-->2-fluoro-2-[4-(trifluoromethyl)phenyl]acetic acid

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