ChemicalBook Product Catalog Chemical Reagents Organic reagents Imide O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE

O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE

O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Basic information
Product Name:O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE
Synonyms:2-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE;FLOROX REAGENT;FLOROX(TM) REAGENT;PFBHA;PFBHA HCL;PENTAFLUOROBENZYLHYDROXYLAMINE HCL;O-(PENTAFLUOROBENZYL)HYDROXYAMINE HYDROCHLORIDE;O-(PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE
CAS:57981-02-9
MF:C7H5ClF5NO
MW:249.57
EINECS:261-057-7
Product Categories:Analytical Chemistry;Boronic Acid, etc. (GC Derivatizing Reagents);GC Derivatizing Reagents;Hydroxylamines;Hydroxylamines (O-Substituted)
Mol File:57981-02-9.mol
O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Structure
O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Chemical Properties
Melting point 227 °C (subl.)(lit.)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 5%, clear
form powder to crystal
color White
PHpH(5g/l, 25℃) : 2.0～3.0
Water Solubility Soluble in water.
BRN 4031190
CAS DataBase Reference57981-02-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25
WGK Germany 3
F 10
HazardClass IRRITANT
HS Code 29280000
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE Usage And Synthesis
Chemical PropertiesWhite powder
UsesO-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride is used in the preparation of oximes of steroids having keto group. It is used as a derivatization reagent in the determination of thromboxane B2, prostaglandins, amygdalin and a variety of aldehydes, ketones and acids. It is a versatile reagent utilized for the detection of carbonyl-containing compounds by gas chromatography (GC), gas chromatography mass spectrometry (GC-MS) and other methods. As a derivatization reagent, it is also used for EC/LC analysis of keto-steroids and carbohydrates.
UsesPFBHA.HCl has been used for derivatization of metabolites with carbonyl groups followed by analysis via GC-MS. It has also been used in aldehyde derivatization followed by aldehydic hydrolysis using GC/MS.
UsesO-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride is used:
  • In the preparation of oximes of steroids-bearing keto group.
  • As a derivatization reagent in the determination of thromboxane B2, prostaglandins, amygdalin, and a variety of aldehydes, ketones, and acids.
It is a versatile reagent used for the detection of carbonyl-containing compounds by GC, GC-MS, and other methods.
General DescriptionO-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA.HCl) is a derivatizing agent.
Purification MethodsRecrystallise the salt from EtOH to form colourless leaflets. Drying the compound at high vacuum and elevated temperature will result in losses by sublimation. [Youngdale J Pharm Sci 65 625 1976, Wehner & Handke J Chromatog 177 237 1979, Nambara et al. give incorrect m as 115-116o J Chromatogr 114 81 1975.]
Ethoxyamine hydrochloride 3,5-Difluorobenzyl alcohol 2,5-Difluorobenzyl alcohol Methoxyammonium chloride 3,4-Difluorobenzyl alcohol 2,3,6-TRIFLUOROBENZYL ALCOHOL O-(4-Fluoro-benzyl)-hydroxylamine hydrochloride 2,3,4,6-TETRAFLUOROBENZYL ALCOHOL O-(3-Fluoro-benzyl)-hydroxylamine hydrochloride 3,4,5-Trifluorobenzenemethanol 2,3,4,5,6-PENTAFLUOROTOLUENE 2,6-Difluorobenzyl alcohol O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE O-Benzylhydroxylamine hydrochloride 2,4-Difluorobenzyl alcohol 2,3,4-Trifluorobenzyl alcohol 2,3-Difluorobenzyl alcohol 2,3,5-Trifluorobenzyl alcohol
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