|
| | tert-Butyl 1-piperazinecarboxylate Basic information | | Uses |
| | tert-Butyl 1-piperazinecarboxylate Chemical Properties |
| Melting point | 43-47 °C(lit.) | | Boiling point | 98-100 | | density | 1.030±0.06 g/cm3(Predicted) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Soluble in DMSO | | pka | 8.45±0.10(Predicted) | | form | Low Melting Crystalline Mass | | color | White to light yellow | | Water Solubility | Soluble in ethyl acetate, methanol and water. | | Sensitive | Air Sensitive | | BRN | 879985 | | InChIKey | CWXPZXBSDSIRCS-UHFFFAOYSA-N | | CAS DataBase Reference | 57260-71-6(CAS DataBase Reference) | | NIST Chemistry Reference | T-butyl 1-piperaziencarboxylate(57260-71-6) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | 3263 | | WGK Germany | 3 | | F | 3-10-34 | | HazardClass | IRRITANT | | HS Code | 29335995 |
| | tert-Butyl 1-piperazinecarboxylate Usage And Synthesis |
| Uses | N-Boc-piperazine is a compound useful in organic synthesis. | | Chemical Properties | Waxy Solid | | Uses | 1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone. | | Uses | 1-Boc-piperazine may be used in:
- preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
- termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
- preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors
| | Application | Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments. | | General Description | 1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine. |
| | tert-Butyl 1-piperazinecarboxylate Preparation Products And Raw materials |
|
