SBE 13 hydrochloride

SBE 13 hydrochloride Basic information
Product Name:SBE 13 hydrochloride
Synonyms:SBE 13 hydrochloride;N-(4-((6-chloropyridin-3-yl)Methoxy)-3-Methoxybenzyl)-2-(3,4-diMethoxyphenyl)ethanaMine hydrochloride;SBE-13 HCl;N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine;N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride;CS-1632;SBE13 HydrochL;SBE 13 hydrochloride >=98% (HPLC)
CAS:1052532-15-6
MF:C24H28Cl2N2O4
MW:479.4
EINECS:
Product Categories:Inhibitors
Mol File:1052532-15-6.mol
SBE 13 hydrochloride Structure
SBE 13 hydrochloride Chemical Properties
storage temp. Sealed in dry,Room Temperature
solubility DMSO: ≥17mg/mL
form powder
color white to tan
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
SBE 13 hydrochloride Usage And Synthesis
DescriptionSBE 13 is a potent inhibitor of polo-like kinase 1 (Plk1) (IC50 = 0.2 nM) that targets the inactive conformation of the enzyme . It exhibits no activity against aurora A kinase and less effectively inhibits Plk2 (IC50 > 66 μM) and Plk3 (IC50 = 875 nM). SBE 13 induces cell cycle arrest, reduces cell proliferation (EC50 = 5-60 μM), and induces apoptosis in a broad range of human cancer cell lines.
UsesSBE13 Hydrochloride is a selective inhibitor of PLK1.
in vitroto determine its ability to induce cell death in cancer cells, we applied kinase assays, western blot analyses, facs can analyses, caspase assays and immunofluorescence studies. we detected decreased cell proliferation, delayed progression through the cell cycle in lower sbe13 concentrations, a g2/m arrest using higher sbe13 concentrations followed by apoptosis, and abnormal mitotic figures. notably, sbe13 did not influence activity of other kinases (plk2, plk3, aurora a), indicating the selectivity of this type ii plk1 inhibitor [1].
SBE 13 hydrochloride Preparation Products And Raw materials
SBE13

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.