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| | Unii-p9vxv1408y Basic information |
| Product Name: | Unii-p9vxv1408y | | Synonyms: | Ceftaroline;Unii-p9vxv1408y;acetic acid,(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,hydrate;Ceftaroline Fosamil Acetate Hydrate;Ceftaroline Impurity8;4-[2-[[(6R;4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methylpyridinium acetate hydrate;7R)-2-Carboxy-7-[[(2Z)-(ethoxyimino)[5-(phosphonoamino)-1 | | CAS: | 866021-48-9 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | Amines;API;Chiral Reagents;Heterocycles | | Mol File: | Mol File | ![Unii-p9vxv1408y Structure]() |
| | Unii-p9vxv1408y Chemical Properties |
| | Unii-p9vxv1408y Usage And Synthesis |
| Definition | ChEBI: Ceftaroline fosamil acetate monohydrate is a hydrate that is the monohydrate form of ceftaroline fosamil acetate. A prodrug for ceftaroline, used for the treatment of adults with acute bacterial skin and skin structure infections. It has a role as an antimicrobial agent, an antibacterial drug and a prodrug. It contains a ceftaroline fosamil acetate. | | Antimicrobial activity | A semisynthetic cephalosporin formulated as the water-soluble
fosamil acetate prodrug for intravenous administration.
Its properties are similar to those of ceftobiprole, with
which it shares an enhanced affinity for penicillin-binding
protein 2′ (2a) of methicillin-resistant Staph. aureus.
It is hydrolyzed by extended-spectrum β-lactamases and is not active against Amp-C derepressed strains of Gram-negative
bacilli. | | Pharmacokinetics | Cmax 600 mg intravenous (1-h infusion): 19 mg/L end infusion
Plasma half-life: 2.6 h
Volume of distribution: 0.37 L/kg
Plasma protein binding :<20%
Like ceftobiprole, ceftaroline fosamil is rapidly hydrolyzed in
plasma after intravenous infusion and excreted principally in urine.
In preliminary clinical studies it appears to be well tolerated. |
| | Unii-p9vxv1408y Preparation Products And Raw materials |
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