2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Basic information
Product Name:2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
Synonyms:2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one;Eltrombopag Impurity 35;2-(3,4-Dimethylphenyl)-5-methyl-1H-pyrazol-3(2H)-one;2-(3,4-dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one;Eltrombopag Intermediate 1;EltroMbopag II;2-Oxo-2,4,5,6,7,7a-Hexahydrothieno [3,2-c] Pyridine;1-(3,4-diMethylphenyl)-3-Methyl-1H-pyrazol-5-ol
CAS:277299-70-4
MF:C12H14N2O
MW:202.25
EINECS:1592732-453-0
Product Categories:
Mol File:277299-70-4.mol
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Structure
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Chemical Properties
Melting point 121.0 to 125.0 °C
Boiling point 338.5±52.0 °C(Predicted)
density 1.121
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka0.79±0.40(Predicted)
color Pale Beige to Light Beige
Safety Information
HS Code 2933.19.9000
MSDS Information
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Usage And Synthesis
Uses2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one Preparation Products And Raw materials
Raw materials3,4-Dimethylphenylhydrazine hydrochloride-->Ethyl acetoacetate
Preparation Products3'-[[1-(3,4-DiMethylphenyl)-1,5-dihydro-3-Methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
Eltrombopag

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