3-Hydroxy-2-naphthalenecarboxylic acid ethyl ester Chemical Properties
Melting point
79.0 to 83.0 °C
Boiling point
291°C(lit.)
density
1.1652 (rough estimate)
refractive index
1.5090 (estimate)
solubility
soluble in Toluene
form
powder to crystal
pka
9.53±0.40(Predicted)
color
White to Orange to Green
Safety Information
HS Code
2918290090
MSDS Information
3-Hydroxy-2-naphthalenecarboxylic acid ethyl ester Usage And Synthesis
Uses
3-Hydroxy-2-naphthalenecarboxylic acid ethyl ester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
To a round bottom flask were added 5 g 3-hydroxy-2-naphthalic acidand 16 mL ethanol. The reaction mixture was refluxed for 6 h. After thecompletion of the reaction, the reaction mixture was cooled down to room temperature and washed with distilled water. The organic layerwas recovered and washed with saturated sodium bicarbonate followedby drying with anhydrous MgSO4. The MgSO4 was removed by filtrationand the filtrate was dried under reduced pressure. The resulted solid waspurified by silica chromatography with petroleum ether and ethyl acetate(10:1, v/v) as eluent to give the compound ethyl 3-hydroxy-2-naphthoate(4.1229 g, yield 70.60%).
3-Hydroxy-2-naphthalenecarboxylic acid ethyl ester Preparation Products And Raw materials
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