ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Amino alcohol derivative L-(+)-Prolinol

L-(+)-Prolinol

L-(+)-Prolinol Basic information
Product Name:L-(+)-Prolinol
Synonyms:L-2-PYRROLIDINEMETHANOL;(-)-L-PROLINOL;L-(+)-PROLINOL;L-PROLINOL;H-PROLINOL;H-PRO-OL;H-L-PRO-OL;(S)-(+)-PROLINOL
CAS:23356-96-9
MF:C5H11NO
MW:101.15
EINECS:245-605-2
Product Categories:APIs;Proline [Pro, P];Chemical Amines;Chiral Building Blocks;Glycidyl Compounds, etc. (Chiral);Synthetic Organic Chemistry;Pharmaceutical Intermediates;Amines;blocks;Amino Alcohols;chiral;Amino alcohols;Amino Acids & Derivatives
Mol File:23356-96-9.mol
L-(+)-Prolinol Structure
L-(+)-Prolinol Chemical Properties
Melting point 42-44℃
alpha 31 º ((c=1,Toluene))
Boiling point 74-76 °C2 mm Hg(lit.)
density 1.036 g/mL at 20 °C(lit.)
refractive index n20/D 1.4853(lit.)
Fp 187 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform
pka14.77±0.10(Predicted)
form Liquid
color Clear colorless to pale yellow
Specific Gravity1.025
optical activity[α]20/D +31°, c = 1 in toluene
Water Solubility Fully miscible in water. Soluble in chloroform.
Sensitive Air Sensitive
BRN 79843
CAS DataBase Reference23356-96-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
F 3-10-23
Hazard Note Irritant/Air Sensitive
HS Code 29221990
MSDS Information
ProviderLanguage
S-2-Hydroxymethyl-pyrrolidine English
ACROS English
SigmaAldrich English
ALFA English
L-(+)-Prolinol Usage And Synthesis
Chemical PropertiesColorless to light yellow liqui
UsesL-Prolinol is an intermediate in the synthesis of Physostigmine and Physostigmine derivative used for treatment of Alzheimer's disease.
Usesrac-Prolinol is an intermediate in the synthesis of Physostigmine and Physostigmine derivative used for treatment of Alzheimer''s disease.
L-(+)-Prolinol Preparation Products And Raw materials
Preparation ProductsBOC-L-Prolinol-->Avanafil-->L-SERINE METHYL ESTER-->SHR1258-->FMOC-PRO-OL-->2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER-->Methanone, [(2S)-2-(hydroxymethyl)-1-pyrrolidinyl](2-nitrophenyl)--->2-Pyrrolidinemethanol, 1-(2-benzothiazolyl)-, (2S)--->2-Pyrrolidinemethanol, 1-(trifluoroacetyl)-, (2S)- (9CI)-->1-((S)-2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone
Z-PRO-ONP SWAINSONINE O-Methyl-L-prolinol, SMP,L-Prolinol-OMe Z-L-PROLINE Ketorolac tromethamine Methyl L-prolinate hydrochloride (S)-(-)-1-BENZYL-2-PYRROLIDINEMETHANOL Dexketoprofen trometamol GLYCYL-L-PROLINE Hydroxymethyl L-Proline BOC-PRO-ONP BOC-L-Prolinol N-2-4-DNP-HYDROXY-L-PROLINE CRYSTALLINE L-(+)-Prolinol TRISTEARIN Fosfomycin tromethamine Pyrrolidine
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