Sodium ascorbate

Sodium ascorbate Basic information
Description References
Product Name:Sodium ascorbate
Synonyms:ASCORBIC ACID SODIUM SALT;L(+)-ASCORBIC ACID SODIUM SALT;L-ASCORBIC ACID SODIUM SALT;L-ASCORBIC ACID NA-SALT;SODIUMASCORBATE,GRANULAR,FCC;SODIUMASCORBATE,GRANULAR,USP;SODIUMASCORBATE,POWDER,USP;SODIUM ASCORBATE (VC-NA) AND ITS DIRECTLY-COMPRESSION GRANULE
CAS:134-03-2
MF:C6H7NaO6
MW:198.11
EINECS:205-126-1
Product Categories:Vitamins and derivatives;Antioxidant;Biochemistry;Sugar Acids;Sugars;Vitamins;Food and Feed Additive;Inhibitors;134-03-2
Mol File:134-03-2.mol
Sodium ascorbate Structure
Sodium ascorbate Chemical Properties
Melting point 220 °C (dec.)(lit.)
alpha 104 º (c=1, H2O 25 ºC)
Boiling point 235 °C
density 1.66
vapor pressure 0Pa at 25℃
refractive index 105.5 ° (C=10, H2O)
storage temp. 2-8°C
solubility H2O: 50 mg/mL
form powder
color white to slightly yellow
PH7.48(1 mM solution);7.71(10 mM solution);7.64(100 mM solution);7.62(1000 mM solution)
Odorodorless
optical activity[α]20/D +105±2°, c = 5% in H2O
Water Solubility 620 g/L (20 ºC)
Merck 14,830
BRN 3767246
Stability:Stable. Incompatible with strong oxidizing agents.
LogP-4.2 at 21.9℃
CAS DataBase Reference134-03-2(CAS DataBase Reference)
EPA Substance Registry SystemSodium ascorbate (134-03-2)
Safety Information
Risk Statements 68
Safety Statements 24/25
WGK Germany 1
RTECS CI7671000
TSCA Yes
HS Code 29362700
Hazardous Substances Data134-03-2(Hazardous Substances Data)
Toxicitysce-hmn:lym 100 mmol/L MUREAV 60,321,79
MSDS Information
ProviderLanguage
L-Ascorbic acid sodium salt English
SigmaAldrich English
ACROS English
ALFA English
Sodium ascorbate Usage And Synthesis
DescriptionSodium ascorbate is sodium salt of ascorbic acid (commonly known as vitamin C), which is approved for use as a food additive in many countries. Sodium ascorbate is consisted of a combination of sodium and vitamin C, which commonly serve as an antioxidant and an acidity regulator in pharmaceutical manufacturing and in the food industry. In this mixture, sodium acts as a buffer, creating a less acidic supplement than those made entirely from vitamin C. It can be easier to tolerate if the digestive system is sensitive to acid. As a vitamin C supplement, it provides both sodium and vitamin C for human body, which is effective to prevent or treat vitamin C deficiency. Besides, studies have shown that taking sodium ascorbate is helpful with cancer prevention and treatment.
Referenceshttps://en.wikipedia.org/wiki/Sodium_ascorbate
http://www.livestrong.com/article/348175-what-are-the-health-benefits-of-sodium-ascorbate/
http://pets.webmd.com/drugs/2/drug-63684/ascorbic-acid-ascorbate-sodium-oral/details

Chemical PropertiesSodium ascorbate occurs as a white or slightly yellow-colored, practically odorless, crystalline powder with a pleasant saline taste.
UsesSodium Ascorbate is an antioxidant that is the sodium form of ascorbic acid. it is soluble in water and provides a nonacidic taste. a 10% aqueous solution has a ph of 7.3–7.6. in water, it readily reacts with atmospheric oxygen and other oxidizing agents, making it valuable as an antioxidant. one part sodium ascorbate is equivalent to 1.09 parts of sodium erythorbate. see ascorbic acid.
UsesL-Ascorbic acid (Vitamin C) is a water soluble molecule used in a wide variety of applications, including cell culture, as a reducing agent that helps reduce oxidative stress.
UsesAs antimicrobial and antioxidant in foodstuffs.
DefinitionChEBI: Sodium ascorbate is an organic sodium salt resulting from the replacement of the proton from the 3-hydroxy group of ascorbic acid by a sodium ion. It has a role as a food antioxidant, a flour treatment agent, a coenzyme, a plant metabolite, a human metabolite, a Daphnia magna metabolite and a reducing agent. It is an organic sodium salt and a vitamin C. It contains a L-ascorbate.
Production MethodsAn equivalent amount of sodium bicarbonate is added to a solution of ascorbic acid in water. Following the cessation of effervescence, the addition of propan-2-ol precipitates sodium ascorbate.
Brand nameAscorbin (Marion Merrell Dow).
General DescriptionMinute crystals or white powder. pH of aqueous solutions 5.6 to 7.0 or even higher (a 10% solution, made from a commercial grade, may have a pH of 7.4 to 7.7).
Air & Water ReactionsWater soluble. Aqueous solutions are subject to quick air oxidation at pH greater than 6.0.
Reactivity ProfileA weak base. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Health HazardSYMPTOMS: Ingestion of 10 grams or more of this type of compound may cause diarrhea.
Fire HazardFlash point data for Sodium ascorbate are not available. Sodium ascorbate is probably combustible.
Flammability and ExplosibilityNotclassified
Pharmaceutical ApplicationsSodium ascorbate is used as an antioxidant in pharmaceutical formulations, and also in food products where it increases the effectiveness of sodium nitrite against growth of Listeria monocytogenes in cooked meats. It improves gel cohesiveness and sensory firmness of fiberized products regardless of vacuum treatment.
It is also used therapeutically as a source of vitamin C in tablets and parenteral preparations.
Biochem/physiol ActionsAscorbic acid exhibits anti-oxidant properties. It is a primary substrate for detoxifying hydrogen peroxide. Ascorbic acid is a co-factor for the synthesis of adrenal steroids and catecholamines. L-Ascorbic acid (Vitamin C) is a water soluble molecule used in a wide variety of applications, including cell culture, as a reducing agent that helps reduce oxidative stress. L-Ascorbate can be regenerated by biological systems.
Safety ProfileHuman mutation data reported. When heated to decomposition it emits toxic fumes of Na2O.
SafetyThe parenteral administration of 0.25-1.00 g of sodium ascorbate, given daily in divided doses, is recommended in the treatment of vitamin C deficiencies. Various adverse reactions have been reported following the administration of 1 g or more of sodium ascorbate, although ascorbic acid and sodium ascorbate are usually well tolerated; see Ascorbic acid. There have been no reports of adverse effects associated with the much lower concentrations of sodium ascorbate and ascorbic acid, which are employed as antioxidants.
The WHO has set an acceptable daily intake of ascorbic acid, potassium ascorbate, and sodium ascorbate, as antioxidants in food, at up to 15 mg/kg body-weight in addition to that naturally present in food.
storageSodium ascorbate is relatively stable in air, although it gradually darkens on exposure to light. Aqueous solutions are unstable and subject to rapid oxidation in air at pH > 6.0.
The bulk material should be stored in a well-closed nonmetallic container, protected from light, in a cool, dry place.
IncompatibilitiesIncompatible with oxidizing agents, heavy metal ions, especially copper and iron, methenamine, sodium nitrite, sodium salicylate, and theobromine salicylate. The aqueous solution is reported to be incompatible with stainless steel filters.
Regulatory StatusGRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IV preparations; oral tablets). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Sodium ascorbate Preparation Products And Raw materials
Raw materialsAscorbic Acid
Preparation ProductsAscorbic Acid
Ascorbic Acid ε-Caprolactone SODIUM ERYTHORBATE Hydroxy silicone oil Ascoric Acid Erythorbic Acid Sodium sulfate Sodium chloride Vitamin E Diclofenac sodium Sodium 4-hydroxybenzenesulfonate Sodium citrate Sodium bicarbonate Sodium hydroxide Sodium erythorbate 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Poly(ε-caprolactone) Spironolactone Ascorbic Acid Sodium

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