4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE

4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE Basic information

Product Name:	4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
Synonyms:	3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine;3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE;4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE;4-Amino-3-iodopyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-;4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine;3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine;7-Iodo-7-deaza-8-aza-adenine
CAS:	151266-23-8
MF:	C5H4IN5
MW:	261.02
EINECS:
Product Categories:	Heterocycle-Pyridine series;pharmacetical
Mol File:	151266-23-8.mol

4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE Chemical Properties

Boiling point	312.3±52.0 °C(Predicted)
density	2.92±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	10.50±0.20(Predicted)
color	White to Light yellow to Light orange
Sensitive	Light Sensitive
λmax	282nm(lit.)

Safety Information

Hazard Codes	Xn
Risk Statements	36/37/38-22
Safety Statements	26-36/37/39-37
TSCA	N
HS Code	29335990

MSDS Information

4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE Usage And Synthesis

Uses

3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine-->4-Aminopyrazolo[3,4-d]pyrimidine-->2H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI)-->N-Iodosuccinimide
Preparation Products	(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine-->1-cyclopentyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine-->5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Zidovudine 3-BROMO-4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-Aminopyrazolo[3,4-d]pyrimidine 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE N4-Benzoylcytosine Pyrrolo[2,3-d]pyrimidin-4-ol 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE 2-Thiouracil 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 4-Amino-7H-pyrrolo[2,3-d]pyrimidine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE Trifluorothymine 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine DEAZAPURINE 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 1H-PYRAZOLO[3,4-D]PYRIMIDINE

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4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE

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