Xylazine

Xylazine Basic information
Product Name:Xylazine
Synonyms:2-(2,6-dimethylanilino)-5,6-dihydro-4h-1,3-thiazine;2-(2,6-dimethylphenylamino)-4h-5,6-dihydro-1,3-thiazine;5,6-dihydro-2-(2,6-xylidino)-4h-1,3-thiazine;5,6-dihydro-2-(2,6-xylidino)-4h-3-thiazine;2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine;Xylazine Base & HCL;Xylazine,2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine hydrochloride;Xylazine (200 mg)
CAS:7361-61-7
MF:C12H16N2S
MW:220.33
EINECS:230-902-1
Product Categories:7361-61-7
Mol File:7361-61-7.mol
Xylazine Structure
Xylazine Chemical Properties
Melting point 140 C
Boiling point 334.2±52.0 °C(Predicted)
density 1.0905 (rough estimate)
refractive index 1.5700 (estimate)
storage temp. -20°C
solubility Soluble in methanol at 50mg/ml. Also soluble in dilute acid solutions.
form Powder
pka7.67±0.20(Predicted)
InChIInChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)
InChIKeyBPICBUSOMSTKRF-UHFFFAOYSA-N
SMILESS1CCCN=C1NC1=C(C)C=CC=C1C
CAS DataBase Reference7361-61-7(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi
Risk Statements 25-36/37/38
Safety Statements 45-37/39-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS XJ0776300
HazardClass 6.1
HS Code 2934990002
ToxicityLD50 in mice (mg/kg): 43 i.v.; 121 s.c.; 240 orally; LD50 in rats (mg/kg): 130 orally (Sagner)
MSDS Information
Xylazine Usage And Synthesis
DescriptionXylazine is an agonist of α2-adrenergic receptors (Ki = 194 nM). It is an analog of clonidine, an α2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard .
OriginatorXylazine,Bayer
UsesAntinociceptive;Alpha-2 adrenergic agonist
UsesXylazine is an α2 class of adrenergic receptor agonist. Xylazine is a clonidine analoque that acts on presynaptic and postsynaptic receptors as an a 2-adrenergic agonist.
DefinitionChEBI: Xylazine is a methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties. It has a role as an emetic, an alpha-adrenergic agonist, a sedative, a muscle relaxant and an analgesic. It is a methylbenzene, a 1,3-thiazine and a secondary amino compound. It is a conjugate base of a xylazine(1+).
Manufacturing Process2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), prepared from 2,6- dimethylaniline with thiophosgene, were added dropwise during 15 min to a well-stirred suspension of 15.0 g (0.2 mole) of 3-aminopropanol-1 in 100 ml of ether. The ether started to boil. Stirring under reflux was continued for 30 min, and the ether was then distilled off. The residue was treated with 100 ml of concentrated hydrochloric acid and boiled under reflux for 30 min. After cooling, it was diluted with water, filtered free from impurities, and the base was precipitated by the addition of concentrated sodium hydroxide solution. When recrystallized from benzene-ligroin, the resulting compound 2-(2,6- dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine, melting point 140-142°C (yield 90% of the theoretical).
Therapeutic FunctionAnalgesic, Anesthetic
General DescriptionXylazine is soluble in methanol (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid and in chloroform. Xylazine is practically insoluble in water and in alkali solutions.
Biochem/physiol ActionsXylazine when used along with ketamine is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.
Mechanism of actionXylazine is marketed as its hydrochloride salt as Rompun (100 mg/mL) and Anased (20 mg/mL) injectable solutions for intravenous administration to horses and dogs, respectively. The actions of xylazine may be reversed by the administration of yohimbine, an indolalkylamine alkaloid, that blocks those α2- adrenoreceptors that are stimulated by xylazine.
Safety ProfilePoison by ingestion, subcutaneous, and intravenous routes. Human systemic effects: change in motor activity, fall in blood pressure, miosis, pleural thickening, pulse rate decrease, somnolence. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Xylazine Preparation Products And Raw materials
Raw materials3-Aminopropanol-->Sodium hydroxide-->Hydrochloric acid-->Thiophosgene
Xylazine Hydrochloride COCO AMINE Chlorodimethylphenylsilane XYLAZINE HYDROCHLORIDEIMP. A (EP): 2,6-DIMETHYLANILINE (2,6-XYLIDINE) Phenothiazine KETAMINE HYDROCHLORIDE/XYLAZINE HYDROCHLORIDE,Ketamine hydrochloride/xylazine hydrochloride solution Buprofezin thiazine Thiamethoxam Hydrochlorothiazide Diethanolamine Chlorothiazide Bis(2-ethylhexyl)amine XYLAZINE IMPURITY E Toltrazuril Xylazine DIAZOXIDE Dihydromyrcenol

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