L-Arginine L-glutamate

L-Arginine L-glutamate Basic information
Product Name:L-Arginine L-glutamate
Synonyms:S(+)-2-AMINO-5-[(AMINOIMINOMETHYL)AMINO]PENTANOIC ACID MONOHYDROCHLORIDE;L-ARGININE GLUTAMATE;L-ARGININE L-GLUTAMATE;L-ARGININE-L-GLUTAMATE MONOHYDROCHLORIDE;L-ARGININE L-GLUTAMATE SALT;L-ARGININE L-GLUTAMIC ACID;L-ARG L-GLU;Arginine, L-, L-glutamate (1:1)
CAS:4320-30-3
MF:C11H23N5O6
MW:321.33
EINECS:224-350-0
Product Categories:amino acid;Amino Acids
Mol File:4320-30-3.mol
L-Arginine L-glutamate Structure
L-Arginine L-glutamate Chemical Properties
Melting point >185°C (dec.)
storage temp. −20°C
solubility Aqueous Acid (Sparingly), Water (Slightly)
form Solid
color White to Off-White
Odorodorless
LogP-1.287 (est)
CAS DataBase Reference4320-30-3(CAS DataBase Reference)
EPA Substance Registry SystemL-Glutamic acid compd. with L-Arginine (1:1) (4320-30-3)
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
L-Arginine L-glutamate English
SigmaAldrich English
L-Arginine L-glutamate Usage And Synthesis
OriginatorModamate,Abbott,US,1960
UsesIntravenous ammonia detoxicant in cases of liver failure.
UsesL-Arginine L-Glutamate is used in the making of solution of arginine glutamate for the healing of radiation-induced skin ulcers in guinea pigs
DefinitionChEBI: Arginine glutamate is a glutamic acid derivative.
Manufacturing ProcessThis salt may be prepared by mixing L-arginine with L-glutamic acid in water and crystallizing the resulting salt from the water by the addition of a polar water miscible organic solvent to the water. For instance, when 17.2 g of Larginine and 14.5 g of L-glutamic acid were dissolved in 155 g of water, a clear homogeneous solution resulted which had a pH of 5.3. This solution was filtered and the filtrate was evaporated at 50°C under reduced pressure to a solution having a solids content of about 45%. Absolute methanol (220 g) was added to the concentrated solution of the salt and this mixture cooled to 5°C for one hour. The resulting solid salt was removed from the mixture by filtration and washed with absolute methanol. After being dried preliminarily in the air, the salt was further dried in a vacuum oven at 60°C for 3 hours. The resulting salt, L-arginine-L-glutamate, weighed 30 g (94.6% of the theoretically possible yield based on the amount of L-arginine and L-glutamic acid employed) and melted at 193-194.5°C with decomposition.
Brand nameModumate (Abbott).
Therapeutic FunctionAmmonia detoxicant (hepatic failure)
General DescriptionWhite powder.
Air & Water ReactionsSlightly soluble in water.
Reactivity ProfileA dipeptide; hence an amide.
Health HazardACUTE/CHRONIC HAZARDS: When heated to decomposition L-Arginine L-glutamate emits toxic fumes.
L-Arginine L-glutamate Preparation Products And Raw materials
Raw materialsL(+)-Arginine-->L-Glutamic acid
Guanidine acetate Glutamate Monoammonium L-glutamate monohydrate L-Arginine-L-pyroglutamate L-Ornithine Mafenide hydrochloride L-Arginine acetate L-Glutamic acid L-glutamic acid monoammonium ARGINASE DL-Arginine hydrochloride monohydrate Arginine arginine aspirin L-Arginine L-glutamate DL-Glutamic acid monohydrate L-Ornithine acetate L(+)-Arginine L-Arginine hydrochloride

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