ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Piperazine compounds 1-BENZHYDRYLPIPERAZINE

1-BENZHYDRYLPIPERAZINE

1-BENZHYDRYLPIPERAZINE Basic information
Product Name:1-BENZHYDRYLPIPERAZINE
Synonyms:1-(diphenylmethyl)-piperazin;1-(Diphenylmethyl)piperazine,97%;AKOS BBS-00003601;AKOS NCG1-0108;TIMTEC-BB SBB003136;N-BENZHYDRYLPIPERAZINE;N-BENZYLHYDRYLPIPERAZINE;1-BENZHYDRYLPIPERAZINE
CAS:841-77-0
MF:C17H20N2
MW:252.35
EINECS:212-667-7
Product Categories:Building Blocks;C16 to C29;Chemical Synthesis;Heterocyclic Building Blocks;Piperazines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Piperaizine;Piperazine derivates;Aromatics
Mol File:841-77-0.mol
1-BENZHYDRYLPIPERAZINE Structure
1-BENZHYDRYLPIPERAZINE Chemical Properties
Melting point 90-93 °C
Boiling point 185°C/2mmHg(lit.)
density 1.0546 (rough estimate)
vapor pressure 0.001Pa at 20℃
refractive index 1.5794 (estimate)
Fp 115 °C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Methanol (Slightly)
form Crystalline Powder
pka9.05±0.10(Predicted)
color White to light yellow
Water Solubility 0.45 g/L (20 ºC)
Sensitive Air Sensitive
BRN 222773
LogP0.6 at 20℃
CAS DataBase Reference841-77-0(CAS DataBase Reference)
NIST Chemistry ReferenceBenzhydryl piperazine(841-77-0)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22
Safety Statements 22-24/25
WGK Germany 3
RTECS TL6465000
F 34
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
Benzhydrylpiperazine English
SigmaAldrich English
ACROS English
ALFA English
1-BENZHYDRYLPIPERAZINE Usage And Synthesis
Chemical Propertieswhite to light yellow crystalline powder
Uses1-(Diphenylmethyl)piperazine [N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene.
UsesCinnarizine (C465300) impurity.
Uses1-Benzhydrylpiperazine is an intermediate used in drug synthesis
Synthesis Reference(s)Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006
General Description1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes. It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(tert-butyl)-o-benzoquinones.
Flammability and ExplosibilityNotclassified
1-BENZHYDRYLPIPERAZINE Preparation Products And Raw materials
Raw materialsPiperazine-->Benzhydrol-->Chlorodiphenylmethane
Preparation ProductsStugeron-->Oxatomide-->Meclozine-->2-(4-Benzhydrylpiperazino)ethyl acetoacetate-->Manidipine-->4-BENZHYDRYLPIPERAZIN-1-YL CARBONYL CHLORIDE
5-(4-BENZHYDRYLPIPERAZINO)-1H-1,2,4-TRIAZOL-3-AMINE 2-(4-BENZHYDRYLPIPERAZINO)-6-(4-METHOXYPHENYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE 4,4'-Difluorobenzhydrylpiperazine 2-(4-BENZHYDRYLPIPERAZINO)-6-PHENYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE HYDROXYZINE PAMOATE 4-BENZHYDRYLPIPERAZINE-1-CARBOTHIOAMIDE Hydroxyzine dihydrochloride LABOTEST-BB LT00772091 1-(2,3,4a,8a-tetrahydro-1,4-benzodioxin-2-ylcarbonyl)-4-benzhydrylpiperazine 4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE 4-BENZHYDRYLPIPERAZINE-1-CARBOXIMIDAMIDE N-Methyl-N'-benzhydrylpiperazine,n-methyl-n’-benzhydrylpiperazin Stugeron 1-(4,4'-Difluorodiphenylmethyl)piperzine dihydrochloride 2-(4-BENZHYDRYLPIPERAZINO)-6-(3-THIENYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE 2-(4-BENZHYDRYLPIPERAZINO)QUINOXALINE BUCLIZINE Meclizine dihydrochloride
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