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Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate Basic information
Product Name:Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate
Synonyms:BUTTPARK 46\18-97;METHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE;Methyl2-chloro-4-(trifluoromethyl)pyrimidine-5-;Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-;Methyl 2-Chloro-4-(trif1uoromethyl) pyridine-5-carboxylate;Methyl 2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxylate;2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid methyl ester;Methyl-2-chloro-4-(trifluoromethyl)pyrimidin-5-carboxylate
CAS:175137-27-6
MF:C7H4ClF3N2O2
MW:240.57
EINECS:
Product Categories:Esters;Pyrazines, Pyrimidines & Pyridazines;Heterocycle
Mol File:175137-27-6.mol
Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate Structure
Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate Chemical Properties
Melting point 253-254 °C
Boiling point 76-78°C 0,5mm
density 1.491
refractive index n20/D1.468
Fp >110℃
storage temp. 2-8°C
pka-5.70±0.29(Predicted)
CAS DataBase Reference175137-27-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22-22
Safety Statements 26-36/37/39-23-51-24/25-22
RIDADR UN 2810 6.1 / PGIII
WGK Germany 3
HazardClass IRRITANT
HS Code 2933599590
MSDS Information
Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate Usage And Synthesis
UsesMethyl 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate is used in the synthetic preparation and discovery of 2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide (G931520) which is a highly selective CB2 receptor agonist for the treatment of inflammatory and neuropathic pain.
Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate Preparation Products And Raw materials
Methylparaben METHYL PYRIMIDINE-5-CARBOXYLATE 2-Chloro-4-(trifluoromethyl)pyrimidine Methyl ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Bensulfuron methyl CYCLOPROPYLMETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-Trifluoromethylbenzyl chloride BENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Difluorochloromethane 5-Methylpyrimidine Kresoxim-methyl Fluorocytosine Thiophanate-methyl Pirimiphos-methyl Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 4-CHLOROBENZYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE METSULFURON METHYL
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