Irsogladine maleate

Irsogladine maleate Basic information
Product Name:Irsogladine maleate
Synonyms:2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinemaleate;2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinmaleate;3,5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-(z)-2-butenedioate(1:1);gaslon;mn-1695;2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate;Irsogladin maleate;Gaslon N
CAS:84504-69-8
MF:C13H11Cl2N5O4
MW:372.16
EINECS:
Product Categories:Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:84504-69-8.mol
Irsogladine maleate Structure
Irsogladine maleate Chemical Properties
Melting point 181-182°C
storage temp. Inert atmosphere,Room Temperature
Water Solubility Insoluble in water
solubility DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM)

form White crystalline powder.
color White to Almost white
Merck 14,5102
CAS DataBase Reference84504-69-8(CAS DataBase Reference)
Safety Information
RTECS XY5930000
HS Code 2933.69.6050
ToxicityLD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)
MSDS Information
Irsogladine maleate Usage And Synthesis
DescriptionIrsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
Chemical PropertiesWhite Solid
UsesAn anti-ulcer drug. Potent PDE4 inhibitor
Usesantiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication
DefinitionChEBI: Irsogladine maleate is a dichlorobenzene.
Biological ActivityPhosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
Irsogladine maleate Preparation Products And Raw materials
Preparation ProductsIrsogladine
6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate Enalapril maleate Maleic acid Maleic anhydride 3,4'-DIAMINODIPHENYLMETHANE Disodium fumarate Cinepazide maleate Dichloromethylphenylsilane Fumaric acid Chlorobenzene Irsogladine Irsogladine maleate Dichlorodiphenylsilane Chlorphenamine maleate 1,3,5-Triazine

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.