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| | cloprednol Basic information |
| Product Name: | cloprednol | | Synonyms: | (11β)-6-Chloro-11,17,21-trihydroxypregna-1,4,6-triene-3,20-dione;Cloprednole;6-Chloro-11β,17,21-trihydroxypregna-1,4,6-triene-3,20-dione;RS-4691;Syntestan;cloprednol;Cloradryn;Novacort | | CAS: | 5251-34-3 | | MF: | C21H25ClO5 | | MW: | 392.876 | | EINECS: | 2260526 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids | | Mol File: | 5251-34-3.mol |  |
| | cloprednol Chemical Properties |
| Melting point | >125°C (dec.) | | Boiling point | 600.3±55.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | Ethyl Acetate (Slightly), Methanol (Slightly) | | pka | 12.30±0.70(Predicted) | | form | Solid | | color | White to Off-White |
| | cloprednol Usage And Synthesis |
| Originator | Syntestan,Syntex,W. Germany,1980 | | Uses | A systematic corticosteroid. Anti-inflammatory. | | Definition | ChEBI: Cloprednol is a 21-hydroxy steroid. | | Manufacturing Process | A mixture of 5 g of the 21-acetate of 6α-chlorohydrocortisone, 7 g of chloranil
and 100 cc of n-amyl alcohol was refluxed for 16 hours, cooled and diluted
with ether. The solution was successively washed with water, 5% sodium
carbonate solution and water, dried over anhydrous sodium sulfate, filtered
and evaporated to dryness under reduced pressure. Chromatographic
purification of the residue yielded the 21-acetate of 6-chloro-δ1,4,6-
pregnatriene-11β,17α,21-triol-3,20-dione. | | Therapeutic Function | Glucocorticoid |
| | cloprednol Preparation Products And Raw materials |
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