ChemicalBook Product Catalog Biochemical Engineering Inhibitors TGF-beta / Smad TGF-beta / Smad inhibitors SD-208

SD-208

SD-208 Basic information
Product Name:SD-208
Synonyms:SD-208;2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE;2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine;2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine;CS-2295;SD-208 (SD 208;SD 208;SD208;TGF-Β RI KINASE INHIBITOR V;4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
CAS:627536-09-8
MF:C17H10ClFN6
MW:352.75
EINECS:
Product Categories:Inhibitors;Smad;TGF-beta
Mol File:627536-09-8.mol
SD-208 Structure
SD-208 Chemical Properties
Boiling point 460.4±45.0 °C(Predicted)
density 1.487
storage temp. 2-8°C
solubility DMSO: >5mg/mL
form powder
pka4.56±0.26(Predicted)
color off-white to tan
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
SD-208 Usage And Synthesis
UsesSD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2
Biological ActivityPotent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.
Biochem/physiol ActionsSD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1
storageStore at RT
SD-208 Preparation Products And Raw materials
1H-INDOLE-5-CARBOXAMIDE, 97% Dabrafenib Lenalidomide LY-364947 LY2109761 SB 431542 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole xav-939
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