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| | (R)-(+)-1,2-Dithiolane-3-pentanoic acid Basic information |
| | (R)-(+)-1,2-Dithiolane-3-pentanoic acid Chemical Properties |
| Melting point | 48-52 °C(lit.) | | alpha | D23 +104° (c = 0.88 in benzene) | | Boiling point | 185-195 °C(Press: 0.5 Torr) | | density | 1.218±0.06 g/cm3(Predicted) | | refractive index | 114 ° (C=1, EtOH) | | Fp | >230 °F | | storage temp. | -20°C | | solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMSO | | pka | 5.4(at 25℃) | | form | Solid | | color | Light Yellow to Yellow | | optical activity | [α]20/D +104°, c = 1 in chloroform | | Merck | 14,9326 | | LogP | 2.160 (est) | | CAS DataBase Reference | 1200-22-2(CAS DataBase Reference) |
| | (R)-(+)-1,2-Dithiolane-3-pentanoic acid Usage And Synthesis |
| Chemical Properties | Yellow Crystalline Solid | | Uses | A fat-metabolism stimulator | | Uses | α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS).
It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection. | | Definition | ChEBI: (R)-lipoic acid is the (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties. It has a role as a prosthetic group, a nutraceutical and a cofactor. It is a lipoic acid, a member of dithiolanes, a heterocyclic fatty acid and a thia fatty acid. It is functionally related to an octanoic acid. It is a conjugate acid of a (R)-lipoate. It is an enantiomer of a (S)-lipoic acid. | | General Description | α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms. | | Biochem/physiol Actions | (R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease. |
| | (R)-(+)-1,2-Dithiolane-3-pentanoic acid Preparation Products And Raw materials |
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