1,3-Butanediol

1,3-Butanediol Basic information
Description References
Product Name:1,3-Butanediol
Synonyms:(±)-butane-1,3-diol;1,3-Butandiol;Methyltrimethylene;Methyltrimethylene glycol;methyltrimethyleneglycol;1-METHYLTRIMETHYLENE GLYCOL;1,3-DIHYDROXYBUTANE;(+/-)-1,3-BUTANEDIOL
CAS:107-88-0
MF:C4H10O2
MW:90.12
EINECS:203-529-7
Product Categories:Anhydrous Solvents;Solvent Bottles;Solvent by Application;Solvent Packaging Options;Solvents;Sure/Seal Bottles;Cnbio
Mol File:107-88-0.mol
1,3-Butanediol Structure
1,3-Butanediol Chemical Properties
Melting point -54 °C
Boiling point 203-204 °C(lit.)
density 1.005 g/mL at 25 °C(lit.)
vapor density 3.1 (20 °C, vs air)
vapor pressure 0.06 mm Hg ( 20 °C)
refractive index n20/D 1.44(lit.)
Fp 250 °F
storage temp. Store below +30°C.
solubility >500g/lMiscible
form Liquid
pka14.83±0.20(Predicted)
color Clear colorless to yellow, may discolor to brown on storage
Specific Gravity1.004 – 1.007
Odorodorless
PH6.1 (500g/l, H2O, 20℃)
PH Range6 - 7 at 20 °C
explosive limit1.9-12.6%(V)
Water Solubility SOLUBLE
Sensitive Hygroscopic
Merck 14,1567
BRN 1731276
Stability:Stable. Flammable. Hygroscopic - protect from air and moisture. Incompatible with strong oxidizing agents.
LogP-0.9 at 25℃
CAS DataBase Reference107-88-0(CAS DataBase Reference)
NIST Chemistry Reference1,3-Butanediol(107-88-0)
EPA Substance Registry System1,3-Butylene glycol (107-88-0)
Safety Information
Safety Statements 24/25
WGK Germany 1
RTECS EK0440000
3
Autoignition Temperature741 °F
TSCA Yes
HS Code 29053920
Hazardous Substances Data107-88-0(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 18610 mg/kg LD50 dermal Rabbit > 20000 mg/kg
MSDS Information
ProviderLanguage
1,3-Butanediol English
SigmaAldrich English
ACROS English
ALFA English
1,3-Butanediol Usage And Synthesis
Description1,3-Butanediol is an organic chemical which belongs to the family of secondary alcohols. At present, 1,3-butanediol is used mainly in surfactants, inks, solvents for natural and synthetic flavoring agents and serves as a co-monomer in manufacturing certain polyurethane and polyester resins. It can also serve as a humectant to prevent loss of moisture in cosmetics, particularly in hair sprays and setting lotions. Besides, 1,3-Butanediol is pharmaceutically involved in the production of colchicine derivatives as a anticancer agent and in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as a hypoglycaemic agent, which is effective for the treatment of diabetes.
Referenceshttps://en.wikipedia.org/wiki/1,3-Butanediol
https://www.trc-canada.com/product-detail/?B690010
http://www.hmdb.ca/metabolites/HMDB31320
https://www.alfa.com/zh-cn/catalog/A11684/


Chemical Properties1,3-Butylene glycol has a sweet flavor with bitter aftertaste and is odorless when pure.
Chemical Propertiescolourless liquid
Chemical PropertiesButylene glycol occurs as a clear, colorless, viscous liquid with a sweet flavor and bitter aftertaste.
Uses1,3-Butanediol is used in the synthesis of colchicine derivatives as anticancer agents. Also used in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycem ic agents in the treatment of diabetes.
UsesIts most extensive use is as an intermediate in the manufacture of polyester plasticisers and other chemical products. It finds some use as a solvent and humectant, a useful chemical intermediate. It has extensive application in the manufacture of structural materials for boats, custom mouldings, and sheets and boards for construction applications. 1,3-Butanediol imparts resistance to weathering plus flexibility and impact resistance. It is also used in the manufacture of saturated polyesters for polyurethane coatings, where the glycol imparts greater flexibility to the polyester molecule. 1,3-Butanediol is currently used in many personal care products.
Uses(^+)-1,3-Butanediol acts as a co-monomer in the production of polyurethane and polyester resins. It is used as a humectant (to prevent loss of moisture) in cosmetics, especially in hair sprays and setting lotions. It is used in surfactants, inks, solvents for natural and synthetic flavorings. It is involved in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycemic agents, which is used in the treatment of diabetes.
PreparationFrom formaldehyde and propylene via pressure and a catalyst.
DefinitionChEBI: A butanediol compound having two hydroxy groups in the 1- and 3-positions.
Production MethodsButylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel.
Aroma threshold valuesDetection: 70 to 100 ppm
General Description(±)-1,3-Butanediol (BD) is a 1,3-diol. Its vapor pressure upto 270kPa, liquid-phase densities over a temperature range, two-phase (liquid + vapor) heat capacities, critical temperature and critical density have been determined. The obtained data was employed to derive various thermophysical properties.
Flammability and ExplosibilityNotclassified
Pharmaceutical ApplicationsButylene glycol is used as a solvent and cosolvent for injectables. It is used in topical ointments, creams, and lotions, and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances.
In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at ~8% concentration. Higher concentrations above 16.7% are required to inhibit fungal growth.
Contact allergensThis dihydric alcohol is used for its humectant and preservative potentiator properties in cosmetics, topical medicaments and polyurethane, polyester, cellophane, and cigarettes. It has similar properties, but is less irritant than propylene glycol. Contact allergies seem to be rare.
Safety ProfileMdly toxic by ingestion and subcutaneous routes. A skin and eye irritant. See also ETHYLENE GLYCOL. Experimental reproductive effects. Combustible when exposed to heat or flame. Incompatible with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
SafetyButylene glycol is used in a wide variety of cosmetic formulations and is generally regarded as a relatively nontoxic material. It is mildly toxic by oral and subcutaneous routes.
In topical preparations, butylene glycol is regarded as minimally irritant. Butylene glycol can cause allergic contact dermatitis, with local sensitivity reported in patch tests. Some local irritation is produced on eye contact.
LD50 (guinea pig, oral): 11.0 g/kg
LD50 (mouse, oral): 12.98 g/kg
LD50 (rat, oral): 18.61 g/kg
LD50 (rat, SC): 20.0 g/kg




CarcinogenicityThere were no tumors found in the 2-year feeding studies on dogs and rats . Thus, it appears that 1,3-butanediol is not carcinogenic.
storageButylene glycol is hygroscopic and should be stored in a well-closed container in a cool, dry, well-ventilated place. When heated to decomposition, butylene glycol emits acrid smoke and irritating fumes.
IncompatibilitiesButylene glycol is incompatible with oxidizing reagents.
Regulatory StatusGRAS listed. Included in the FDA Inactive Ingredients Database (transdermal patches). Included in licensed medicines in the UK (topical gel patches/medicated plasters).
1,3-Butanediol Preparation Products And Raw materials
Raw materialsPROPYLENE-->Butyraldehyde-->ALDOL
Preparation Products1,3-Dimethoxybutane
1-BUTENE Diethylene glycol (+/-)-1,2-BUTANEDIOL,1,2-BUTANEDIOL GlycolEthers CHRYSAZIN(RG) 3-Diethylaminophenol 1,4-Butanediol 1-Hydroxyethylidene-1,1-diphosphonic acid 2,3-Butanediol DIHYDROXY BENZALDEHYDE 2-Methyl-2,4-pentanediol 1,3-Dihydroxyacetone Triclosan Ethylene glycol Dipropylene glycol N-BUTANE 2-Butoxyethanol 2-Butoxyethyl acetate

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