Penciclovir

Penciclovir Basic information
Product Name:Penciclovir
Synonyms:9-[4-hychoxy-3-(hydvoxymethyl)butyl]guanine;BRL-39123;BRL-39123A;Vectavir;PENCICLOVIR-D4;Penciceovir;6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-;9-[4-Hydroxy-3-(hydroxymethyl)butyl]guanine
CAS:39809-25-1
MF:C10H15N5O3
MW:253.26
EINECS:663-371-3
Product Categories:DENAVIR;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Isotope Labeled Compounds;API's;39809-25-1
Mol File:39809-25-1.mol
Penciclovir Structure
Penciclovir Chemical Properties
Melting point 275-277°C
Boiling point 653.4±65.0 °C(Predicted)
density 1.68±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 0.02 M potassium phosphate: soluble2mg/mL
pka14.42±0.10(Predicted)
form White solid
color White to Off-White
λmax253nm(H2O)(lit.)
Merck 14,7083
CAS DataBase Reference39809-25-1(CAS DataBase Reference)
EPA Substance Registry System6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]- (39809-25-1)
Safety Information
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
WGK Germany 3
RTECS UP0789400
HS Code 2933.99.8290
Hazardous Substances Data39809-25-1(Hazardous Substances Data)
Penciclovir Usage And Synthesis
DescriptionVectavir was launched in the UK for herpes labialis. Penciclovir is synthetically available by two routes of four steps each from 2- (hydroxymethyl)butane-l,4-diol and is active against HSV-1, HSV-2 VZV but has limited activity against CMV. Vectavir is an acyclic guanosine analog that acts as a competitive inhibitor of DNA polymerase. It is a metabolic product of famcyclovir that is preferentially phosphorylated by viral infected cells (by thymidine kinases) over normal cells. The triphosphate has a low activity against cellular DNA polymerase which is one possible explanation for its low toxicity. While its spectrum of activity is similar to acyclovir, it is longer acting because its triphosphate is 20 times more stable and is not metabolized.
Chemical PropertiesWhite Cyrstalline Solid
OriginatorSmithKline Beecham (UK)
UsesAn antiviral.
UsesA deuterated version of Penciclovir, an antiviral
DefinitionChEBI: A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclo ir, is used for oral administration.
IndicationsPenciclovir has activity against HSV-1, HSV-2, VZV, and HBV. After oral administration, famciclovir is converted to penciclovir by first-pass metabolism. Penciclovir has a mechanism of action similar to that of acyclovir. It is first monophosphorylated by viral thymidine kinase; then it is converted to a triphosphate by cellular kinases.
Manufacturing ProcessTo a suspension of lithium aluminum hydride (2.87 g, 76 mmol) in tetrahydrofuran (125 ml), a solution of triethyl 1,1,2-ethanetricarboxylate (9.2 ml, 9.85 g, 40 mmol) in tetrahydrofuran (25 ml) was added dropwise with stirring over 2 hours. The inorganic salts were filtered off and washed with ethanol (100 ml). The filtrate and washings were combined and the solvent was evaporated under reduced pressure to afford a colourless oil (4.85 g). To a suspension of this oil in acetone (100 ml) 2,2-dimethoxypropane (25 ml) and p-toluenesulphonic acid monohydrate (2.3 g, 12 mmol) were added. The mixture was stirred for 1 hour. The resulting solution was neutralised with Amberlite IR 45 (methanol washed), filtered and the solvent evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with chloroform-methanol mixtures (40:1 and 25:1) to afford 5-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan as a colourless liquid (3.01 g, 47%).
To an ice-cooled solution of 5-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan (1.92 g, 12 mmol) and carbon tetrabromide (7.96 g, 24 mmol) in dimethylformamide (100 ml) triphenylphosphine (6.30 g, 24 mmol) was added and the solution was left at 4°C overnight. To this solution methanol (20 ml) was added and the solvent was then evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with hexane-acetone (12:1) to afford 5-(2-bromoethyl)-2,2-dimethyl1,3-dioxan as a clear colourless liquid (0.89 g, 40%).
To a solution of 5-(2-bromoethyl)-2,2-dimethyl-1,3-dioxan (0.75 g, 3.7 mmol) in dry dimethylformamide (12 ml) 2-amino-6-chloropurine (0.68 g, 4.0 mmol) and then anhydrous potassium carbonate (0.83, 6.0 mmol) were added. The solution was stirred at room temperature for 5 hours and left at 4°C overnight. The solution was filtered and the solvent removed. The residue was purified by column chromatography on silica gel, eluting with chloroformmethanol mixtures (80:1 and 60:1) to afford 2-amino-6-chloro-9-[2-(2,2dimethyl-1,3-dioxan-5-yl)ethyl]purine as a white crystalline solid (0.74 g, 64%), melting point 125°-126°C.
2-Amino-6-chloro-9-[2-(2,2-dimethyl-1,3-dioxan-5-yl)-ethyl]purine (0.59 g, 1.9 mmol) in hydrochloric acid (1.0 M, 4 ml) was stirred at 60°C for 24 hours. The solution was diluted with water and neutralised with Amberlite IR 45. The mixture was filtered, the resin washed with water and the solvent evaporated under reduced pressure. The residue was recrystallised from water to afford 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (238 mg, 49%), melting point 275°-277°C.


Brand nameDenavir (SmithKline Beecham).
Therapeutic FunctionAntiviral
Acquired resistancePenciclovir is inactive against thymidine kinase-deficient strains of HSV.
Pharmaceutical ApplicationsA synthetic acyclic purine nucleoside analog, usually administered orally as the diacetyl ester, famciclovir, which acts as a prodrug undergoing rapid first-pass metabolism to release the active compound in vivo. The parent compound has virtually no oral bioavailability, but is supplied as a topical formulation.
PharmacokineticsOral absorption, penciclovir: 5%
famciclovir: 77%
Cmax famciclovir 250 mg oral: 1.6 mg/L after 0.5–1.5 h
famciclovir 500 mg oral: 3.3 mg/L after 0.5–1.5 h
famciclovir 750 mg oral: 5.1 mg/L after 0.5–1.5 h
Plasma half-life: 2.1–2.7 h
Volume of distribution: c. 1.5 L/kg
Plasma protein binding: <20%
Following absorption famciclovir is converted rapidly by enzyme-mediated deacetylation and oxidation to penciclovir. Food does not lead to any significant change in the availability or elimination.
The pharmacokinetics in elderly subjects are similar to those seen in younger subjects, although small increases in AUC and plasma half-lives were seen, consistent with slightly decreased renal clearance.
Renal excretion is the major route of elimination, 50–60% of an oral dose being recovered in the urine. After intravenous infusion, about 70% is excreted unchanged in the urine. After oral administration of famciclovir, penciclovir accounts for 82% of urinary drug-related material. The remainder includes metabolites, of which the largest is the 6-deoxy precursor of penciclovir. Renal clearance exceeds glomerular filtration, indicating renal tubular secretion.





Clinical UsePenciclovir is approved as a topical formulation for the treatment of herpes labialis. In immunocompetent individuals, penciclovir shortens the duration of lesion presence and pain by approximately half a day when it is initiated within an hour of lesion development and applied every 2 hours during waking hours for 4 days.
Clinical UseHerpes zoster and genital herpes
Orolabial herpes (topical)
Side effectsIn clinical trials the incidence of adverse events after famciclovir, aciclovir and placebo were similar, the most common adverse events being headache and nausea.
references[1] boyd m r, bacon t h, sutton d, et al. antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl) guanine (brl 39123) in cell culture. antimicrobial agents and chemotherapy, 1987, 31(8): 1238-1242.
[2] hodge r a, perkins r m. mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl) guanine (brl 39123) against herpes simplex virus in mrc-5 cells. antimicrobial agents and chemotherapy, 1989, 33(2): 223-229.
2-[2-(2-AMINO-9H-PURIN-9-YL)ETHYL]-1,3-PROPANEDIOL N-t-Boc-valacyclovir Acyclovir IMpurity C N-Methyl Valganciclovir Hydrochloride Famciclovir N7-Isomer 9-(2'-ACETOXYETHOXYMETHYL)-GUANINE FAMCICLOVIR-D4 Famciclovir Related Compound A (20 mg) (2-[2-(2-Amino-9H-purin-9-yl)ethyl]propane-1,3-diol hydrochloride) MONO-DESACETYL FAMCICLOVIR FaMciclovir Related CoMpound C FaMciclovir iMpurity 5 BRL 42222 FaMciclovir iMpurity 7 9-(4-hydroxybutyl)guanine Entecavir hydrate 1,9-Dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-on e monosodium salt PENCICLOVIR, [8-3H]- 6H-PURIN-6-ONE, 1,9-DIHYDRO-9-[3-[[(4-METHOXYPHENYL)DIPHENYLMETHOXY]METHYL]-4-[[(4-METHYLPHENYL)SULFONYL]OXY]BUTYL]-2-[[(4-METHOXYPHENYL)DIPHENYLMETHYL]AMINO]-

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.