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| | Triethyl orthoacetate Chemical Properties |
| Boiling point | 142 °C (lit.) | | density | 0.885 g/mL at 25 °C (lit.) | | vapor pressure | 3.4 hPa (20 °C) | | refractive index | n20/D 1.396(lit.) | | RTECS | KJ4075000 | | Fp | 97 °F | | storage temp. | Store below +30°C. | | solubility | soluble in Chloroform, Ethyl Acetate | | form | Liquid | | color | Clear colorless to slightly yellow | | explosive limit | 0.9-7.0%(V) | | Water Solubility | SLIGHTLY SOLUBLE | | Sensitive | Moisture Sensitive | | BRN | 506201 | | LogP | 2.6 at 20℃ | | CAS DataBase Reference | 78-39-7(CAS DataBase Reference) | | NIST Chemistry Reference | Ethane, 1,1,1-triethoxy-(78-39-7) | | EPA Substance Registry System | Ethane, 1,1,1-triethoxy- (78-39-7) |
| Hazard Codes | Xi | | Risk Statements | 10-36/38 | | Safety Statements | 26-37/39-16 | | RIDADR | UN 3272 3/PG 3 | | WGK Germany | 1 | | Autoignition Temperature | 455 °C | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29159080 |
| | Triethyl orthoacetate Usage And Synthesis |
| Description | Triethyl orthoacetate is the ethyl orthoester of acetic acid. It is an oily liquid with a pungent odor. Triethyl orthoacetate is used as a water scavenger and as intermediate for synthesis of pharmaceuticals. It is used in organic synthesis for the introduction of the acetate group to an alcohol and in the Johnson-Claisen rearrangement.
| | Reference |
- J. S. Lindsey, I. C. Schreiman, H. C. Hsu, P. C. Kearney, A. M. Marguerettaz, Rothemund and Adler-Longo reactions revisited: synthesis of tetraphenylporphyrins under equilibrium conditions, The Journal of Organic Chemistry, 1987, vol. 52, pp. 827-836
- R. C. Capozza, Polymeric orthoesters housing beneficial drug for controlled release therefrom, Patent US4066747A
| | Chemical Properties | clear colourless liquid | | Uses | Intermediate. | | Uses | Triethyl orthoacetate is used as pharmaceutical and water scavenger. It is also used in organic synthesis to introduce the acetate group into an alcohol. It is involved in the Johnson-Claisen rearrangement. | | Hazard | Moderate fire risk. | | Flammability and Explosibility | Flammable |
| | Triethyl orthoacetate Preparation Products And Raw materials |
| Raw materials | Sodium chloride-->Ammonium chloride-->4-Chlorobenzaldehyde-->Acetamide-->Sodium ethylate solution,in ethyl alcohol-->Trimethyl orthoacetate-->Thymol Blue | | Preparation Products | Permethrin-->1,2-Phenylenediacetic acid-->ethyl 3,3-dimethylpent-4-en-1-oate-->BROTIZOLAM-->4-Amino-6-methylpyrimidine-5-carbonitrile ,97%-->ethyl 4,6,6-trichloro-3,3-dimethyl-hex-5-enoate-->Diethyl acetamidomalonate-->Tazarotene-->4,4,4-TRICHLOROACETOACETIC ACID ETHYL ESTER-->2-ethylquinazolin-4-ol-->6-BROMO-2-METHYLOXAZOLO[4,5-B]PYRIDINE-->2-[3-(DIMETHYLAMINO)-1-METHOXY-2-PROPENYLIDENE]MALONONITRILE-->1,3,5(10), 9(11)-ESTRATETRAEN-3-OL-17-ONE-->ETHYL TRANS-4-DECENOATE-->4-Octenoic acid, 6-methyl-, ethyl ester, (E)- (9CI) |
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