Pyridaben

Pyridaben Basic information
Uses Acute Toxicity Carcinogenicity Neurotoxicity Environmental Fate and Toxicity
Product Name:Pyridaben
Synonyms:Shaomanjing;Pyridaben E.C.,penetrating;2-T-BUTYL-5-(4-T-BUTYLBENZYLTHIO)-4-CHLOROPYRIDAZIN-3(2H)-ONE;Hsdb 7052;Pyridaben [iso];Pyridaben 1g [96489-71-3];Proposed;BAS 300
CAS:96489-71-3
MF:C19H25ClN2OS
MW:364.93
EINECS:405-700-3
Product Categories:Agro-Products;Amines;N-PPesticides;OthersAlphabetic;Heterocycles;Sulfur & Selenium Compounds;INSECTICIDE;PU - PZ;AcaricidesPesticides&Metabolites;Alpha sort;Insecticides;P;Pesticides;Pesticides&Metabolites;Agro-Chemicals
Mol File:96489-71-3.mol
Pyridaben Structure
Pyridaben Chemical Properties
Melting point 111-112°
Boiling point 429.9±55.0 °C(Predicted)
density 1.2 g/cm3
storage temp. 0-6°C
solubility Chloroform: Slightly Soluble
pka-2.69±0.20(Predicted)
form neat
Merck 13,8057
BRN 7933972
LogP6.370
CAS DataBase Reference96489-71-3(CAS DataBase Reference)
NIST Chemistry ReferencePyridaben(96489-71-3)
EPA Substance Registry SystemPyridaben (96489-71-3)
Safety Information
Hazard Codes T;N,N,T
Risk Statements 23/25-50/53
Safety Statements 36/37-45-60-61
RIDADR UN 3077
WGK Germany 3
RTECS UR6149000
HazardClass 6.1(a)
PackingGroup II
Hazardous Substances Data96489-71-3(Hazardous Substances Data)
ToxicityLD50 in male, female rats, bobwhite quail, mallard ducks (mg/kg): 435, 358, >2250, >2500 orally (Hirata); LD50 in male, female rabbits (mg/kg): >2000, >2000 dermally (Hirata)
MSDS Information
ProviderLanguage
Pyridazinone English
Pyridaben Usage And Synthesis
UsesPyridaben (NC-129, BAS 3001) is widely used as an acaricide with a long residual action and as an insecticide mainly against sucking insects. Trade names include Nexter, Oracle, Poseidon, Pyramite, Sanmite, and Starling.
Acute ToxicityPyridaben shows moderate to low acute toxicity to mammals. The intraperitoneal LDso was 68 mg/kg in male rats (Igarashi and Sakamoto, 1994). The dermal toxicity is low but toxicity by the inhalation route is quite high. With sublethal doses in mice and rats, clinical signs included decreased food consumption, diarrhea, hypothermia, bradycardia, bradypnea, decreased spontaneous motor activity, abnormal gait, prostration, eye closing, amd piloerection. At near lethal or lethal doses (300 mg/kg or more) depression of the central nervous and cardiovascular systems were stronger, but no change occurred in motor functions, including coordination, muscle strength, and neuromuscular transmission, or in sensory functions. Early gastric lavage was effective in presenting poisoning in rats and loperamide was efficacious in reducing the diarrhea that occurred at low doses.
CarcinogenicityPyridaben was not oncogenic in typical lifetime feeding studies in the rat and mouse. It is classified by the U.S. Environmental Protection Agency as a Group E compound (no evidence for carcinogenicity to humans).
NeurotoxicityPyridaben caused only a low degree of acute neurotoxicity in a standard battery of neurobehavioral tests when given at a single oral dose of 200 mg/kg in males. Effects included piloerection, hypoactiviy, tremors, and lowered body temperature, but these were sporadic and transient. In a longer term (90 day) study in rats, no neurotoxicity or neuropathology was seen at oral doses up to 27 mg/kg/day, but plasma cholinesterase activity was reduced in females.
Environmental Fate and ToxicityPyridaben has a low acute toxicity to birds, but it is extremely toxic to aquatic species. Its persistence in soil is relatively brief due to rapid microbial degradation (e.g., the half-life under aerobic conditions is reported to be less than 3 weeks). In natural water in the dark, the half-life is about 10 days, due mainly to microbial action since pyridaben is stable to hydrolysis over the pH range 5-9. The half-life including aqueous photolysis is about 30 min at pH 7 (Tomlin, 2000).
Chemical PropertiesBeige Solid
Chemical PropertiesWhite to tan crystalline solid or powder. Faint vanilla odor. Commercial product is available as an emulsifiable concentrate or wettable powder.
UsesPyridaben is a pyridazinone derivative used as an acaricide.
DefinitionChEBI: Pyridaben is a pyridazinone, an organochlorine insecticide and an organochlorine acaricide. It has a role as a mitochondrial NADH:ubiquinone reductase inhibitor.
Agricultural UsesInsecticide, Acaricide: Used to control mites, whiteflies, leafhoppers and psyllids on fruit trees, vegetables, ornamentals and other field crops. Pyramite is a selective contact miticide/insecticide that controls pests in apple, grapes, pear, pistachio, stone fruits, and the tree nuts group[83].
Trade nameBAS®-300; NCI®-129; NESTER®; PYRAMITE®; SANMITE®
Potential ExposurePyridaben is a pyridazinone insecti- cide/acaricide/miticide used to control mites, whiteflies, leafhoppers and psyllids on fruit trees, vegetables, orna- mentals and other field crops. It is also used to control pests in apple, grapes, pear, pistachio, stone fruits, and the tree nuts group .
ShippingUN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2902 Pesticides, liquid, toxic. UN2902 Pesticides, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
IncompatibilitiesDust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, perox- ides, permanganates, perchlorates, chlorine, bromine, fluo- rine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste DisposalIt is the responsibility of chemical waste generators to determine the toxicity and physical properties and of a discarded chemical and to properly identify its classification and certification as a haz- ardous waste and to determine the disposal method. United States Environmental Protection Agency guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult and follow all regional, national, state and local hazardous waste laws to ensure complete and accurate classification and disposal methods. Follow recommendations for the disposal of pesticides and pesticide containers. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
Methylparaben 4-CHLORO-2-(1,1-DIMETHYLETHYL)-5-MERCAPTO-3(2H)-PYRIDAZINONE Methyl Hydralazine Pyridaphenthion tert-Butyl methyl ether tert-Butyl hydrazine Basic Violet 1 Difluorochloromethane N-(TERT-BUTYL)-2-CHLOROACETAMIDE Kresoxim-methyl PHENYL VALERATE SULFACHLOROPYRIDAZINE Pyridaben Methanol Methyl acrylate N-TERT-BUTYLACRYLAMIDE tert-Butylhydrazine hydrochloride

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