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Nicotinamide-N-oxide

Nicotinamide-N-oxide Basic information
Product Name:Nicotinamide-N-oxide
Synonyms:1-OXY-NICOTINAMIDE;3-(AMINOCARBONYL)PYRIDINIUM-1-OLATE;AKOS 94294;NICOTINAMIDE 1-OXIDE;NICOTINAMIDE N-OXIDE;TIMTEC-BB SBB004187;3-Pyridinecarboxamide, 1-oxide;3-Pyridinecarboxamide,1-oxide(9CI)
CAS:1986-81-8
MF:C6H6N2O2
MW:138.12
EINECS:217-859-4
Product Categories:Amines, Heterocycles, Metabolites & Impurities, Nicotine Derivatives, Nucleotides, Bases & Related Reagents;Amines;Bases & Related Reagents;Heterocycles;Metabolites & Impurities;Nicotine Derivatives;AMIDE;Biochemicals and Reagents;NAD and Analogs;Nucleosides, Nucleotides, Oligonucleotides;Nucleotides
Mol File:1986-81-8.mol
Nicotinamide-N-oxide Structure
Nicotinamide-N-oxide Chemical Properties
Melting point 291-293 °C (dec.)(lit.)
Boiling point 253.51°C (rough estimate)
density 1.3471 (rough estimate)
refractive index 1.5100 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka14.38±0.50(Predicted)
form Solid
color White to Off-White
Sensitive Hygroscopic
CAS DataBase Reference1986-81-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 29339900
MSDS Information
ProviderLanguage
3-(Aminocarbonyl)pyridinium-1-olate English
ACROS English
SigmaAldrich English
Nicotinamide-N-oxide Usage And Synthesis
DescriptionNicotinamide N-oxide is a metabolite of nicotinamide . It is formed via oxidation of nicotinamide by the cytochrome P450 (CYP) isoform CYP2E1. Nicotinamide N-oxide (30 mM) inhibits proliferation and induces reduction of nitroblue tetrazolium (NBT; ), indicating cell differentiation, in HL-60 promyelocytic leukemia cells. Urine levels of nicotinamide N-oxide are elevated in a mouse model of high-fat diet-induced obesity.
Chemical PropertiesWHITE TO SLIGHTLY YELLOW FLUFFY CRYST. NEEDLES
UsesA metabolite of Nicotinamide.
DefinitionChEBI: Nicotinamide N-oxide is a member of pyridines.
Nicotinamide-N-oxide Preparation Products And Raw materials
Raw materialsAcetic acid-->Hydrogen peroxide-->Nicotinamide
Preparation ProductsForchlorfenuron-->2-Aminonicotinic acid-->2-Chloronicotinamide-->2-chloro-5-cyanopyridine
Nicotinic acid Nicotinamide SPECS AC-907/25005501 ETHYLENE OXIDE Ramixotidine (Diethoxymethyl)diphenylphosphine oxide Iron oxide Zinc oxide THIONICOTINAMIDE Pyridinium chlorochromate Nicotine NITRIC OXIDE 2-PHENOXY-3-(([2-(PHENYLSULFONYL)ETHYL]AMINO)CARBONYL)PYRIDINIUM-1-OLATE 3-[((2-[(4-METHYLPHENYL)SULFONYL]ETHYL)AMINO)CARBONYL]-2-PHENOXYPYRIDINIUM-1-OLATE Nicotinamide-N-oxide NITROUS OXIDE Magnesium oxide Propylene oxide
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