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| | TAXIFOLIN 3-O-RHAMNOSIDE Basic information |
| Product Name: | TAXIFOLIN 3-O-RHAMNOSIDE | | Synonyms: | Taxifolin 3-o-rhamnoside;Astilbin Taxifolin 3-O-rhaMnoside;Taxifolin 3-rhaMnoside;Astilbin froM Engelhardtia roxburghiana;Dihydroquercetin 3-rhamnoside;(2R,3R)-3-[(6-Deoxy-alpha-L-mannopyranosyloxy)]-2-(3,4-dihydroxy-phenyl)-2,3-dihydro-5,7-dihydroxy-4H-chromen-4-one;(2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one;(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one | | CAS: | 29838-67-3 | | MF: | C21H22O11 | | MW: | 450.4 | | EINECS: | 694-695-3 | | Product Categories: | Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 29838-67-3.mol |  |
| | TAXIFOLIN 3-O-RHAMNOSIDE Chemical Properties |
| Melting point | 180 °C (decomp) | | Boiling point | 801.1±65.0 °C(Predicted) | | density | 1.74 | | storage temp. | Sealed in dry,2-8°C | | solubility | H2O: soluble1mg/mL, clear, colorless | | pka | 7.34±0.60(Predicted) | | form | A crystalline solid |
| Hazard Codes | N | | Risk Statements | 50 | | Safety Statements | 61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | HS Code | 29389090 |
| | TAXIFOLIN 3-O-RHAMNOSIDE Usage And Synthesis |
| Description | Astilbin is a flavonoid that has been found in S. glabra and has diverse biological activities. It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive oxygen species (ROS) in HEK293 cells when used at a concentration of 200 μM. Astilbin (50 mg/kg) increases renal glutathione (GSH) levels and superoxide dismutase (SOD) and catalase activity and reduces serum creatinine and blood urea nitrogen (BUN) levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity. It reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinson''s disease when administered at a dose of 50 mg/kg per day. Astilbin also reduces descent time in a pole test and increases traction test score in a mouse model of Parkinson''s disease, indicating reduced motor deficits. It reduces cell viability of MDA-MB-231 and MCF-7 cells (IC50s = 167.9 and 191.6 μM, respectively), as well as inhibits migration and increases apoptosis when used at concentrations of 50 and 200 μM. Astilbin (20 mg/kg every other day for 14 days) reduces tumor growth in an MCF-7 mouse xenograft model. | | Uses | Astilbin displays anti-depressant activity involving monoaminergic neurotransmitters an the BDNF signal pathway. Anti-oxidant. | | Definition | ChEBI: A flavanone glycoside that is (+)-taxifolin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage. |
| | TAXIFOLIN 3-O-RHAMNOSIDE Preparation Products And Raw materials |
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