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(R)-3-Hydroxypyrrolidine

(R)-3-Hydroxypyrrolidine Basic information
Product Name:(R)-3-Hydroxypyrrolidine
Synonyms:(3R)-3-PYRROLIDINOL;(3R)-Pyrrolidin-3-ol;R-(+)-3-PYRROLIDINOL 98%;(R)-(+)-3-HYDROXYPYRROLIDINE , EE 99%;(R)-(+)-3-Hydroxypyrrolidine, 99%, ee 99%;(3R)-Pyrrolidine-3-ol;(R)-Pyrrolidine-3-ol;(R)-(+)-3-Pyrrolidinol,98%
CAS:2799-21-5
MF:C4H9NO
MW:87.12
EINECS:628-839-3
Product Categories:pharmacetical;API intermediates;Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry
Mol File:2799-21-5.mol
(R)-3-Hydroxypyrrolidine Structure
(R)-3-Hydroxypyrrolidine Chemical Properties
Melting point 15°C
alpha 6.5 º (c=3.5% in MeOH)
Boiling point 215-216 °C (lit.)
density 1.078 g/mL at 20 °C (lit.)
refractive index n20/D 1.488(lit.)
Fp >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka14.91±0.20(Predicted)
form Viscous Liquid
color Clear yellow to orange-brown
Specific Gravity1.048
optical activity[α]20/D +6.5°, c = 3.5 in methanol
Water Solubility Soluble in water and methanol.
Sensitive Air Sensitive & Hygroscopic
BRN 5376132
CAS DataBase Reference2799-21-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 3
F 10-34
Hazard Note Irritant
HS Code 29339900
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
(R)-3-Hydroxypyrrolidine Usage And Synthesis
Chemical Propertiesclear yellow to orange-brown viscous liquid
Uses(R)-Pyrrolidin-3-ol is used in preparation of allosteric BCR-ABL bifunctional proteolysis targeting chimera compounds.
Purification MethodsThe (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]
(R)-3-Hydroxypyrrolidine Preparation Products And Raw materials
Raw materialsEthyl acetate-->Methanol-->Tetrahydrofuran-->Dichloromethane-->Lithium Aluminum Hydride-->Palladium-->Sodium borohydride-->Xylene-->Benzylamine-->iodine-->D(+)-Malic acid
Povidone iodine RETRORSINE N-Methyl-2-pyrrolidone (2S,4R)-1-Acetyl-4-hydroxypyrrolidine-2-carboxylic acid H-PRO-HYP-OH N-Vinyl-2-pyrrolidone Polyvinylpyrrolidone CYTOCHALASIN E H-GLY-HYP-OH Boc-Hyp-OH H-GLY-PRO-HYP-OH METHYL-2-PYRROLIDONE BOC-HYP(BZL)-OH H-HYP-GLY-OH PLATYPHYLLINE BITARTRATE 3-Pyrrolidinol (R)-3-Hydroxypyrrolidine Pyrrolidine
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