2-Amino-2-methyl-1,3-propanediol

2-Amino-2-methyl-1,3-propanediol Basic information
Product Name:2-Amino-2-methyl-1,3-propanediol
Synonyms:1,1-Di(hydroxymethyl)ethylamine;1,3-Dihydroxy-2-methyl-2-propylamine;1,3-Propanediol, 2-amino-2-methyl-;2-amino-2-methyl-3-propanediol;2-Amino-2-methylpropan-1,3-diol;2-Amino-2-methylpropane-1,3-diol;2-Amino-2-methylpropanediol;2-AMINO-2-METHYL-1,3-PROPANEDIOL 98+%
CAS:115-69-5
MF:C4H11NO2
MW:105.14
EINECS:204-100-7
Product Categories:buffer;API intermediates;Industrial/Fine Chemicals
Mol File:115-69-5.mol
2-Amino-2-methyl-1,3-propanediol Structure
2-Amino-2-methyl-1,3-propanediol Chemical Properties
Melting point 100-110 °C (lit.)
Boiling point 151 °C/10 mmHg (lit.)
density 1.0509 (estimate)
vapor density 3.63 (vs air)
vapor pressure ~10 mm Hg ( 152 °C)
refractive index 1.4754 (estimate)
Fp >100°C
storage temp. Store below +30°C.
solubility H2O: 1 M at 20 °C, clear, colorless
form Crystalline Powder
color White
PH10.0-12.0 (20℃, 0.5M in H2O)
pka8.8(at 25℃)
PH Range7.8 - 9.7
Water Solubility 2500 g/L (20 ºC)
λmaxλ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.03
Merck 13,447
BRN 635708
Stability:Stable. Combustible. May be moisture-sensitive. Incompatible with strong oxidizing agents, copper, aluminium, brass, strong acids.
LogP-1.31 at 22℃
CAS DataBase Reference115-69-5(CAS DataBase Reference)
NIST Chemistry Reference2-Amino-2-methyl-1,3-propanediol(115-69-5)
EPA Substance Registry System1,3-Propanediol, 2-amino-2-methyl- (115-69-5)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22
Safety Statements 26-36-37/39
RIDADR UN 3259 8/PG 2
WGK Germany 1
RTECS TY2975000
3-23
TSCA Yes
PackingGroup III
HS Code 29221980
ToxicityLD50 orally in Rabbit: 17000 mg/kg
MSDS Information
ProviderLanguage
AMPD English
SigmaAldrich English
ACROS English
2-Amino-2-methyl-1,3-propanediol Usage And Synthesis
Chemical Propertieswhite powder
UsesEmulsifying agent (in soap form) for oils, fats, and waxes; absorbent for acidic gases; organic synthesis; cosmetics.
UsesA useful biological buffer2-Amino-2-methyl-1,3-propanediol is used to make surfactants, vulcanization accelerators and as a biological buffer. It acts as an absorbent for acidic gases and emulsifying agent for cosmetics, mineral oil, leather dressings, textile specialties and cleaning compounds. It is also used in hair sprays. It acts as a buffer for the determination of alkaline phosphatase activity and spacer in isotachophoresis of proteins. It serves as a reaction buffer for enzymes with an activity in the basic pH range such as alkaline phosphatase. Further, it is used in the preparation of 4-hydroxymethyl-4-methyl-oxazolidin-2-one.
DefinitionChEBI: An aminodiol that is propane-1,3-diol substituted ny an amino and a methyl group at position 2.
Purification MethodsCrystallise the diol three times from MeOH, dry in a stream of dry N2 at room temperature, then in a vacuum oven at 55o. Store it over CaCl2 [Hetzer & Bates J Phys Chem 66 308 1962]. [Beilstein 4 IV 1881.]
2-Amino-2-methyl-1,3-propanediol Preparation Products And Raw materials
Preparation Products1,3-Propanediol, 2-methyl-2-[(phenylmethyl)amino]--->Crisnatol-->MFCD24849117
4-METHYLUMBELLIFERYL PHOSPHATE, BIS(2-AMINO-2-METHYL-1,3-PROPANEDIOL) SALT,4-METHYLUMBELLIFERYL PHOSPHATE DI-(2-AMINO-2-METHYL-1,3-PROPANEDIOL) SALT Methyl 2-[(1-Hydroxychrysen-6-ylmethyl)amino]-2-methyl-1,3-propanediol BOC-2-AMINO-2-METHYL-1,3-PROPANEDIOL FMOC-2-AMINO-2-METHYL-1,3-PROPANEDIOL 2-METHYL-1,3-PROPANEDIOL 2-[([1,1'-biphenyl]-4-ylmethyl)amino]-2-methyl-1,3-propanediol 2,4-DIMETHYL-4-HYDROXYMETHYL-2-OXAZOLINE 5-BROMO-4-CHLORO-3-INDOLYLPHOSPHATE BIS-(2-AMINO-2-METHYL-1,3-PROPANEDIOL)-SALT 2-Amino-2-methyl-1,3-propanediol (1.08091) ALPHA-METHYL-DL-SERINE 2-AMINO-2-METHYL-1,3-PROPANEDIOL CONCENTRATE Phenolphthalein monophosphate bis-(2-amino-2-methyl-1,3-propanediol) salt 2-[[[(1S,2S)-1,2-Dihydroxy-1,2-dihydrochrysen]-6-ylmethyl]amino]-2-methyl-1,3-propanediol Thiophanate-methyl Pirimiphos-methyl 2-({[5-(2,5-dichlorophenyl)-2-furyl]methyl}amino)-2-methyl-1,3-propanediol 2-[[[(1R,2R)-1,2-Dihydroxy-1,2-dihydrochrysen]-6-ylmethyl]amino]-2-methyl-1,3-propanediol

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