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| | DIMETHYLPHOSPHINE OXIDE Basic information |
| Product Name: | DIMETHYLPHOSPHINE OXIDE | | Synonyms: | Methylphosphinoylmethane;DIMETHYLPHOSPHINOUS ACID;DIMETHYLPHOSPHINE OXIDE;Keto-Dimethyl-Phosphonium;Dimethylphosphine Oxide
Dimethyl-Oxo-Phosphonium;Dimethyl-Oxophosphonium;Phosphine oxide, dimethyl- (6CI,8CI,9CI);Einecs 230-591-2 | | CAS: | 7211-39-4 | | MF: | C2H7OP | | MW: | 78.05 | | EINECS: | 230-591-2 | | Product Categories: | | | Mol File: | 7211-39-4.mol |  |
| | DIMETHYLPHOSPHINE OXIDE Chemical Properties |
| Boiling point | 65-67 °C(Press: 6 Torr) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | liquid | | color | white solid to light yellow | | Sensitive | air sensitive |
| | DIMETHYLPHOSPHINE OXIDE Usage And Synthesis |
| Description | Dimethylphosphine oxide is an organophosphorus compound. It can be used for the preparation of triacrylphosphine oxide. It can be used as an asymmetric catalyst. In addition, it can be used for the preparation of alkenyldiphenylphosphine oxides, and Horner-Witting reagents. In addition, it is also a kind of capping ligand in organic chemistry.
| | Chemical Properties |
Dimethylphosphine oxide is a colorless liquid that soluble in polar organic solvents.It exists as the phosphine oxide, not the hydroxy tautomer.
| | Uses | Dimethylphosphine Oxide is used in preparation of substituted piperazine derivatives as DGKα/DGKζ inhibitors for the treatment of viral infections and cancer. | | Reactions |
Chlorination gives dimethylphosphoryl chloride. It undergoes hydroxymethylation with formaldehyde.
Me2P(O)H+CH2O→Me2P(O)CH2OH
Many aldehydes effect a similar reaction.
| | References | https://en.wikipedia.org/wiki/Dimethylphosphine_oxide
http://www.sigmaaldrich.com/catalog/product/aldrich/287881?lang=en®ion=US
Ganesan, Paramasivam, and S. Lakshmipathi. "Impact of heterogeneous passivation of trimethylphosphine oxide and di-methylphosphine oxide surface ligands on the electronic structure of Cd n Se n, (n =6, 15) quantum dots: A DFT study." Physica E: Low-dimensional Systems and Nanostructures 83(2016):284-296.
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| | DIMETHYLPHOSPHINE OXIDE Preparation Products And Raw materials |
| Raw materials | Phosphinous amide, N,N,P,P-tetramethyl--->dimethyl methylthiophosphine-->Phosphinous amide, N,N-diethyl-P,P-dimethyl--->Phosphinous amide, P,P-dimethyl-N,N-bis(1-methylethyl)--->Phosphinous acid, dimethyl-, methyl ester (8CI,9CI)-->DIMETHYLPHOSPHINIC ACID-->CHLORO(DIMETHYL)PHOSPHINE-->Diethyl phosphite-->Methylmagnesium chloride | | Preparation Products | Benzenamine, 4-(dimethylphosphinyl)-2-methoxy- |
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