L-Norvaline

L-Norvaline Basic information
Product Name:L-Norvaline
Synonyms:L-2-AMinopentanoic-d5 Acid;L-Norvaline arginase inhibitor;L-Novvaline;Norvaline| H-Nva-OH;H-Nva-OH(L-Norvaline);L(+)-Norvaline, 99% 1GR;L-Norvaline, 97+%;H-L-NORVALINE
CAS:6600-40-4
MF:C5H11NO2
MW:117.15
EINECS:229-543-3
Product Categories:Pyridines;amino acid;Norvaline [Nva];Amino Acids;Unusual Amino Acids;Perindopril intermediate;chiral;PROTECTED AMINO ACID & PEPTIDES;Pharmaceutical Intermediates;Amino Acids;bc0001
Mol File:6600-40-4.mol
L-Norvaline Structure
L-Norvaline Chemical Properties
Melting point >300 °C(lit.)
alpha 24.5 º (c=10, 6 N HCl)
Boiling point 222.9±23.0 °C(Predicted)
density 1.2000 (estimate)
refractive index 25 ° (C=10, 6mol/L HCl)
storage temp. Store below +30°C.
solubility 48.7g/l
pka2.32(at 25℃)
form Fine Crystalline Powder
color White
Water Solubility 10.5 g/100 mL (18 ºC)
Merck 14,6716
BRN 1721162
CAS DataBase Reference6600-40-4(CAS DataBase Reference)
NIST Chemistry ReferenceL-Norvaline(6600-40-4)
Safety Information
Hazard Codes C,Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 24/25-37/39-26
WGK Germany 3
HS Code 29224995
MSDS Information
ProviderLanguage
L(+)-2-Aminovaleric acid English
ACROS English
SigmaAldrich English
ALFA English
L-Norvaline Usage And Synthesis
DescriptionL-Norvaline, an amino acid nutritional supplements, is a nonessential amino acid that’s typically found in protein-rich foods, such as meat and eggs. And, it can also be made by the body from valine during normal metabolism. L-norvaline is frequently consumed by athletes as part of their workout supplement program. It is usually used for pre-workout drinks to boost energy and support post-workout recovery. During workouts, L-norvaline improves muscle tissue strength and endurance by providing massive amounts of oxygen and nutrients.
Chemical Propertieswhite to light yellow crystal powder
UsesL-Norvaline is a protein amino acid used as a skin-conditioning and anti-static agent. It is also used in method for reducing misincorporation of non-canonical branched-chain Amino Acids into recombinant proteins.
DefinitionChEBI: L-Norvaline is a 2-aminopentanoic acid that has S-configuration. It has a role as a bacterial metabolite. It is a (R)-fenbuconazole and a 2-aminopentanoic acid. It is an enantiomer of a D-2-aminopentanoic acid. It is a tautomer of a L-2-aminopentanoic acid zwitterion.
benefitsSome benefits with taking L-norvaline:
L-Norvaline increases blood flow to working muscles, which can lead to greater muscle pumps during workouts, less soreness after workouts, and faster recovery times between workouts.
L-Norvaline, an amino acids supplement for men, may support nitric oxide production in healthy individuals, where nitric oxide plays an important role in many biological processes in the body including muscular contraction, blood circulation and blood flow throughout the body.
Biochem/physiol ActionsL-Norvaline enhances NO production from activated macrophages.
Side effectsMild gastrointestinal symptoms such as stomach irritation, nausea, and vomiting may result from L-Norvaline supplementation.
SafetyResearchers from the University of Technology Sydney found taking the amino acid L-norvaline, even in small doses, could make cells unhealthy and eventually kill them.
However, in a study published in the US National Library of Medicine National Institutes of Health dated December 17, 2019, and entitled “Reports of L-Norvaline Toxicity in Humans May Be Greatly Overstated”, it was argued that the quantities of L-Norvaline used in the study claiming its toxicity was greatly above cytotoxic levels for all amino acids. Hence, it was concluded in the said study that as long as L-Norvaline is taken within recommended doses, it will not necessarily cause cytotoxic effects.
A typical dose of L-Norvaline is around 100mg-250mg per day.
Purification MethodsCrystallise norvaline from aqueous EtOH or water. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2390-2399 1961, Beilstein 4 III 1331-1333, 4 IV 128, 2629.]
L-Norvaline Preparation Products And Raw materials
Preparation Products2-Oxopentanoic acid-->BOC-NVA-OH
Estradiol valerate MAGNESIUM DIPROPYLACETATE HYDRATE Hyaluronic acid Betamethasone 17-valerate DL-NORVALINE SIGMA GRADE,DL-NORVALINE 98% Valeric acid Ethyl 2-(Chlorosulfonyl)acetate N-EPSILON-ACETYL-L-LYSINE Pivalic acid N-ALPHA-BENZOYL-L-ARGININE Valine Folic acid L-β-Homophenylalanine, HPLC 98% 2-Propylpentanoic acid L-Norvaline gamma-Benzyl L-glutamate D-NORVALINE SIGMA GRADE,D(-)-NORVALINE 99% 5-AMINOVALERIC ACID

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