4-(Trifluoromethyl)benzoic acid

4-(Trifluoromethyl)benzoic acid Basic information

Product Name:	4-(Trifluoromethyl)benzoic acid
Synonyms:	4-(trifluoromethyl)-benzoicaci;Benzoic acid, 4-(trifluoromethyl)-;4-(TRIFLUOROMETHYL)BENZOIC ACID;A,A,A-TRIFLUORO-P-TOLUIC ACID;ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLUIC ACID;PTF-BOA;P-TRIFLUOROMETHYLBENZOIC ACID;RARECHEM AL BO 0066
CAS:	455-24-3
MF:	C8H5F3O2
MW:	190.12
EINECS:	207-242-8
Product Categories:	Benzotrifluoride Series;Carboxylic Acids;blocks;Carboxes;Boronic Acid series;Phenyls & Phenyl-Het;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic Acids;Phenyls & Phenyl-Het;API intermediates;bc0001
Mol File:	455-24-3.mol

4-(Trifluoromethyl)benzoic acid Chemical Properties

Melting point	219-220 °C(lit.)
Boiling point	247°C 753mm
density	1.3173 (estimate)
Fp	247°C/753mm
storage temp.	Sealed in dry,Room Temperature
pka	3.69±0.10(Predicted)
form	Fine Crystalline Powder
color	White to slight gray
Water Solubility	Soluble in water.
BRN	2049241
CAS DataBase Reference	455-24-3(CAS DataBase Reference)
NIST Chemistry Reference	«ALPHA»,«alpha»,«alpha»-trifluoro-p-toluic acid(455-24-3)
EPA Substance Registry System	Benzoic acid, 4-(trifluoromethyl)- (455-24-3)

Safety Information

MSDS Information

4-(Trifluoromethyl)benzoic acid Usage And Synthesis

Uses	4-(Trifluoromethyl)benzaldehyde is a reactant that has been used in the preparation of N,N'-(Arylmethylene)bisamides with cytotoxic activity as anti cancer agents.
Chemical Properties	White to light yellow crystal powde
Uses	4-(Trifluoromethyl)benzoic acid was used in the synthesis of salicylanilide 4-(trifluoromethyl)benzoates via?N,N?-dicyclohexylcarbodiimide coupling in dry N,N-dimethylformamide. It was used as internal standard during the ultra trace analysis of fluorinated aromatic carboxylic acids by GC/MS method.
Definition	ChEBI: A benzoic acid carrying a 4-trifluoromethyl substituent.

4-(Trifluoromethyl)benzoic acid Preparation Products And Raw materials

Raw materials	4-Methylbenzotrifluoride-->4-trifluoromethylbenzeneboronic acid neopentyl glycol ester-->trimethyl(4-(trifluoromethyl)phenyl)silane-->4-TRIFLUOROMETHYLPHENYLBORONIC ACID, PINACOL ESTER-->4-Bromobenzotrifluoride-->4-(Trifluoromethyl)benzyl alcohol-->4-Chlorobenzotrifluoride
Preparation Products	4-(TRIFLUOROMETHYL)PHENYL ISOCYANATE-->alpha,alpha,alpha-Trifluoro-o-toluoyl chloride-->4-Trifluoromethylsalicylic acid-->4'-(TRIFLUOROMETHYL)PROPIOPHENONE-->2-AMINO-4-(TRIFLUOROMETHYL)BENZOIC ACID-->N-(4-Methoxybenzyl)-4-(trifluoroMethyl)benzaMide, 97%

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