Promazine hydrochloride

Promazine hydrochloride Basic information
Product Name:Promazine hydrochloride
Synonyms:10-(3-(Dimethylamino)propyl)phenothiazine monohydrochloride;10-(3-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(3-(dimethylamino)propyl)-phenothiazinhydrochloride;10-(3-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(gamma-Dimethylamino-n-propyl)phenothiazine hydrochloride;Chlorpromazine EP Impurity C HCl;n,n-dimethyl-10h-phenothiazine-10-propanamine hydrochloride;PROMAZINE HCL
CAS:53-60-1
MF:C17H21ClN2S
MW:320.88
EINECS:200-179-7
Product Categories:SPARINE;Active Pharmaceutical Ingredients;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:53-60-1.mol
Promazine hydrochloride Structure
Promazine hydrochloride Chemical Properties
Melting point 174-176?C
density 1.1435 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form neat
color White
BRN 3753230
CAS DataBase Reference53-60-1(CAS DataBase Reference)
NIST Chemistry ReferenceN,N-dimethyl-10H-phenothiazine-1-propanamine hydrochloride(53-60-1)
EPA Substance Registry SystemPromazine hydrochloride (53-60-1)
Safety Information
Hazard Codes Xn
Risk Statements 22-43
Safety Statements 36
WGK Germany 3
RTECS SO8575000
HS Code 2934302300
MSDS Information
ProviderLanguage
SigmaAldrich English
Promazine hydrochloride Usage And Synthesis
Chemical PropertiesWhite Solid
UsesPromazine hydrochloride has been used in conductivity and surface tension measurements and for testing inhibition of feline coronavirus (FCoV) in Felis catus whole fetus-4 (fcwf-4) cells.
UsesAntipsychotic. Tranquilizer.
DefinitionIsomeric with promethazine hydrochloride.
Brand nameSparine (Baxter Healthcare); Sparine (Wyeth).
General DescriptionPromazine hydrochloride (PMZ) belongs to the phenothiazine drug family. Promazine is a D2 dopamine receptor antagonist and has antipsychotic and anticholinergic functionality. It is used for pain management and is also used for treating hypersensitivity reactions.
Biochem/physiol ActionsD2 dopamine receptor antagonist; phenothiazine antipsychotic.
Clinical UseAntipsychotic for agitation and restlessness
Safety ProfilePoison by ingestion, subcutaneous, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, tremors, antipsychotic effects. An addltive permitted in food for human consumption; also permitted in the feed and drinhng water of animals and/or for the treatment of food-producing animals. When heated to decomposition it emits toxic fumes of NOx, SOx, and HCl
Drug interactionsPotentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone.
Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide, dronedarone and amiodarone - avoid with amiodarone and dronedarone.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
Antidepressants: increase concentrations and additive antimuscarinic effects, notably with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
Antiepileptics: antagonised (convulsive threshold lowered).
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
Desferrioxamine: avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.
Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval - avoid with amiodarone, disopyramide and dronedarone.
Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid.
Antidepressants: increased level of tricyclics (possibly increased risk of ventricular arrhythmias and antimuscarinic side effects); increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine.
Anticonvulsant: antagonises anticonvulsant effect.
Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.









MetabolismPromazine undergoes considerable first-pass metabolism in the gut wall. It is also extensively metabolised in the liver and is excreted in the urine and faeces in the form of numerous active and inactive metabolites.
Promazine hydrochloride Preparation Products And Raw materials
Promethazine hydrochloride Levomepromazine hydrochloride Phenothiazine N,N-Dimethylformamide Topotecan hydrochloride ETHANE (-)-2-[METHYLAMINO]-1-PHENYLPROPANE D/L-AMPHETAMINE HYDROCHLORIDE Cetirizine hydrochloride Dimethyl sulfide Imipramine hydrochloride Dimethyl fumarate Dimethyl sulfoxide Dimethyl ether Dimethyl carbonate Isopropylamine DIOXOPROMETHAZINE HCL Dimethyl sulfate

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