4-Nitrophenyl chloroformate

4-Nitrophenyl chloroformate Basic information
Product Name:4-Nitrophenyl chloroformate
Synonyms:CHLOROFORMIC ACID 4-NITROPHENYL ESTER;4-NITROPHENYL CHLOROFORMATE;4-Nitrophenyl chloroforMate, 97% 25GR;Formic acid, chloro-, p-nitrophenyl ester;p-Nitrophenoxycarbonyl chloride;ForMic acid, chloro-, p-nitrophenyl ester (6CI,7CI,8CI);4-Nitrophenyl carbonochloridoate, 4-[(Chlorocarbonyl)oxy]nitrobenzene;4-Nitrophenyl Chloroformate >90%
CAS:7693-46-1
MF:C7H4ClNO4
MW:201.56
EINECS:231-706-9
Product Categories:Pharmaceutical intermediates;Protection & Derivatization Reagents (for Synthesis);Synthetic Organic Chemistry;blocks;BuildingBlocks;NitroCompounds;Miscellaneous
Mol File:7693-46-1.mol
4-Nitrophenyl chloroformate Structure
4-Nitrophenyl chloroformate Chemical Properties
Melting point 77-79 °C(lit.)
Boiling point 159-162 °C19 mm Hg(lit.)
density 1.5719 (rough estimate)
refractive index 1.6000 (estimate)
Fp >110°C
storage temp. 2-8°C
solubility Soluble in acetone, chloroform, acetone, toluene and benzene.
form isopropanol suspension
color White to yellow-beige
Water Solubility decomposes
Sensitive Lachrymatory
BRN 518127
Stability:Stable. Incompatible with strong bases, acids. Combustible.
CAS DataBase Reference7693-46-1(CAS DataBase Reference)
NIST Chemistry ReferenceCarbonochloridic acid, 4-nitrophenyl ester(7693-46-1)
EPA Substance Registry SystemCarbonochloridic acid, 4-nitrophenyl ester (7693-46-1)
Safety Information
Hazard Codes C,T,Xi,F
Risk Statements 34-36/37-23/24/25-41-36/37/38-11-67-36
Safety Statements 26-36/37/39-45-38-28A-36-16-27
RIDADR UN 3261 8/PG 2
WGK Germany 3
19-21
Hazard Note Toxic/Corrosive/Lachrymator
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 29159020
MSDS Information
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4-Nitrophenyl chloroformate Usage And Synthesis
Chemical PropertiesCream solid
Uses4-Nitrophenyl chloroformate can be used:
  • As a reagent for the activation of amines, alcohols and thiols.
  • In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles).
  • In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property.
  • In the preparation of poly(oxyethylene) modified dextrans.
  • To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.
Uses4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane.
Uses4-Nitrophenyl Chloroformate is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules.
4-Nitrophenyl chloroformate Preparation Products And Raw materials
Preparation ProductsTemozolomide-->Z-GLY-ONP-->Z-LEU-ONP-->FMoc-Val-Cit-PAB-PNP-->L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]--->5-AMINO-2-METHYLBENZOTHIAZOLE-->Temozolomide Impurity-->Carbonic acid, 4-nitrophenyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl ester-->cyclohexyl (4-nitrophenyl) carbonate-->4-(Phenoxycarbonylamino)benzeneboronic acid pinacol ester, 95%-->N-Ethyl-N-methyl-O-(4-nitrophenyl)carbamate-->4-Nitrophenyl 4-(pyridin-2-yldisulfanyl)benzyl carbonate
4-(tert-Butyl)benzyl mercaptan Diisopropyl chlorophosphate 4-Nitrobenzyl chloroformate 4-Nitroanisole 2-NITROPHENYL CHLOROFORMATE Chloromethyl methyl ether P-NITROPHENYL CHLOROFORMATE-ACTIVATED*CROSS-LINKED4 p-Nitrobenzoic acid 4-NITROPHENYL ACETATE 1-Chloroethyl chloroformate o-Nitrophenyl chloroformate 4-Nitrophenyl phosphate bis(cyclohexylammonium) salt 4-Nitrophenyl formate 4-Nitrophenyl chloroformate Chloroformate Nitrophenyl 4-Nitrosophenol P-ANISIDINE HYDROCHLORIDE

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