Chrysin

Chrysin Basic information
Product Name:Chrysin
Synonyms:AKOS NCG1-0026;5,7-DIHYDROXYFLAVONE;5,7-dihydroxy-2-phenyl-4h-benzo[b]pyran-4-one;5,7-DIHYDROXY-2-PHENYL-CHROMEN-4-ONE;LABOTEST-BB LT00440772;CHRYSIN;CHRYSINE;Chrysin 99.0%min
CAS:480-40-0
MF:C15H10O4
MW:254.24
EINECS:207-549-7
Product Categories:chemical reagent;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors;Intermediates;FINE Chemical & INTERMEDIATES;Di-substituted Flavones;Biochemistry;Flavonoids;Pharmaceutical intermediate
Mol File:480-40-0.mol
Chrysin Structure
Chrysin Chemical Properties
Melting point 284-286 °C(lit.)
Boiling point 357.45°C (rough estimate)
density 1.2693 (rough estimate)
refractive index 1.4872 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka6.50±0.40(Predicted)
form Crystalline Powder
color Yellow
Merck 14,2256
BRN 233276
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyRTIXKCRFFJGDFG-UHFFFAOYSA-N
LogP3.520
CAS DataBase Reference480-40-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-36-26
WGK Germany 3
RTECS LK8329050
10
HazardClass IRRITANT
HS Code 29329990
MSDS Information
ProviderLanguage
5,7-Dihydroxy-2-phenyl-4H-benzo[b]pyran-4-one English
ACROS English
SigmaAldrich English
ALFA English
Chrysin Usage And Synthesis
DescriptionChrysin is a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties. It blocks COX-2 gene expression, PGE2 production, and hydroxyl radical formation in LPS-induced RAW 264.7 cells. Chrysin inhibits insulin-induced HIF-1α expression (~50% at 10 μM) in human prostate cancer DU145 cells and blocks DU145 xenograft-induced angiogenesis in vivo. In a mouse model of ischemia/reperfusion injury, chrysin decreased pro-inflammatory gene expression and oxidative stress, resulting in a reduction of infarct volume and neurological defects.
Chemical Propertiesbeige powder or Pale yellow prismatic crystal (crystallized from methanol) with a melting point of 285°C. This substance is soluble in alkali hydroxide solution and acetone, slightly soluble in ether, ethanol and chloroform, insoluble in water.
UsesChrysin is a flavanoid with anti-inflammatory effect and potential protective effects against cancer and cardiovascular disease. Studies show that Chrysin is central benzodiazepine receptor ligand with possible anxiolytic effects. Chrysin was initially believed to have aromatase inhibitor but recent in vivo studies have disproved that. Dyes and metabolites.
Definition ChEBI: Chrysin is a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. It has a role as an anti-inflammatory agent, an antineoplastic agent, an antioxidant, a hepatoprotective agent, an EC 2.7.11.18 (myosin-light-chain kinase) inhibitor and a plant metabolite. It is a dihydroxyflavone and a 7-hydroxyflavonol.
Biological FunctionsChrysin, also referred to as 5,7-dihydroxyflavone, is a naturally occurring antioxidant flavonoi. It holds immense potential for diverse applications and is being investigated as a potential therapeutic agent for various conditions and diseases. Research on chrysin has revealed its antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic properties, along with its ability to modulate the activity of specific enzymes, hormones, and neurotransmitters. Its therapeutic potential extends to areas like oncology, diabetes, and neurological disorders. Although the precise mechanism of action of chrysin is not yet fully comprehended, research suggests its ability to modulate the activity of enzymes, hormones, and neurotransmitters. For instance, it has shown the potential to influence the activity of aromatase, an enzyme involved in estrogen production. Moreover, chrysin has exhibited inhibitory effects on cancer cell growth and inflammation by influencing the activity of specific enzymes and hormones. It was discovered that Chrysin inhibits HIF-1α (hypoxia-inducible factor-1α) and induces apoptosis.
targetNOS | COX | TNF-α | PGE | IL Receptor | PI3K | Akt | Caspase | NF-kB | TGF-β/Smad
SourceThe main sources of chrysin are honey and propolis, of which the content of chrysin in honey is 5.3 mg/kg and that in propolis is 28 g/L. In addition, chrysin is also found in various vegetables, fruits, herbs, and even mushrooms. Another source of populin is an endophytic fungus Chaetomium globosum, which is related to Chaetomorpha media from India. In addition, chrysin exists in the form of glycosides in walnut, walnut skin, walnut flower and pericarp passion fruit, and in the form of 6-c-arabinoside-8-c-glucoside or glucuronic acid ester in Pinellia ternata.
MORIN 2,2-Bis(hydroxymethyl)propionic acid AVICULARIN (ethylenedioxy)dimethanol CHRYSAZIN(RG) 3-Diethylaminophenol 1-Hydroxyethylidene-1,1-diphosphonic acid DIHYDROXY BENZALDEHYDE Benzo[b]thien-2-ylboronic acid 1,3-Dihydroxyacetone PHENYL VALERATE 2,2-Bis(hydroxymethyl)butyric acid Triclosan Chrysin FLAVONE Butylated Hydroxytoluene 7-HYDROXYFLAVONE Phenylacetic acid

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