8-Hydroxyquinoline sulfate

8-Hydroxyquinoline sulfate Basic information
Product Name:8-Hydroxyquinoline sulfate
Synonyms:Chinosol 8-Hydroxyquinoline Sulfate Oxine Sulfate 8-Quinolinone Sulfate;Quinolin-1-ium-8-ol sulfate;8-Quinolinol·0.5sulfuric acid;8-Quinolinol hemisulfate salt,8-Hydroxyquinoline hemisulfate salt;8-Hydroxyquinoline sulfate, synthesis grade;Oxyquinoline Sulfate (200 mg);8-Quinophenol sulfate;8-Quinolinol Sulfate 
CAS:134-31-6
MF:2C9H7NO.H2O4S
MW:388.4
EINECS:205-137-1
Product Categories:Quinoline derivatives;strong pincer compound;Hydroxyquinolines;Quinolines
Mol File:134-31-6.mol
8-Hydroxyquinoline sulfate Structure
8-Hydroxyquinoline sulfate Chemical Properties
Melting point ~175 °C
density 1.3819 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.5364 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form crystalline
color yellow
Water Solubility >=10 g/100 mL at 19 ºC
Merck 14,4843
BRN 3760550
InChIKeyMRUMAIRJPMUAPZ-UHFFFAOYSA-N
LogP2.42 at 25℃
CAS DataBase Reference134-31-6(CAS DataBase Reference)
EPA Substance Registry System8-Quinolinol sulfate (134-31-6)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
RIDADR 2811
WGK Germany 1
RTECS VC8260000
3-10
HazardClass 6.1(b)
PackingGroup III
HS Code 29339900
MSDS Information
ProviderLanguage
Bis(8-hydroxyquinolinium) sulphate English
SigmaAldrich English
8-Hydroxyquinoline sulfate Usage And Synthesis
Chemical PropertiesCrystalline
OriginatorChinosol,Chinosolfabrik
UsesPharmaceutic aid (complexing agent).
Usesoxyquinoline sulfate is a disinfectant and a preservative against fungus growth. It is made from phenols.
Uses8-Hydroxyquinoline sulfate is used to control grey mould (Botrytis cinevea) in vine grafting. It is also used as a soil sterilant against damping off in seed beds.
Manufacturing ProcessThe mixture of 1.4 kg o-nitrophenol, 2.1 kg o-aminophenol, 6 kg glycerine (d = 1.26) and 5 kg sulfuric acid (d = 1.848) was heated at reflux to temperature 130°-140°C. This temperature was kept for 1.5 hours. The obtained oxyquinoline precipitated, the liquid was removed with water-steam distillation. The residue was diluted with water and alkalized with sodium hydroxide and sodium carbonate to the strong alkaline reaction. The repeated distillation with water steam gave the oil, which hardened as the long needles by cooling. MP: 75°-76°C recrystallized from diluted ethanol.
In practice it is usually used as sulfate salt
Therapeutic FunctionAntiseptic
General DescriptionPale yellow to yellow crystalline powder with a slight saffron odor. Burning taste.
Air & Water ReactionsWater soluble.
Reactivity ProfileA sulfate acidic salt of an amine that is also a phenol. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Fire HazardFlash point data for 8-Hydroxyquinoline sulfate are not available, but 8-Hydroxyquinoline sulfate is probably combustible.
Flammability and ExplosibilityNotclassified
Metabolic pathwayLittle published information is available.
DegradationThe salt and free base of 8-hydroxyquinoline sulfate are very stable but alkali liberates quinolin-8-ol which precipitates heavy metals (PM). 8-Hydroxyquinoline is a chelate ligand of transition metals such as copper.
8-Hydroxyquinoline sulfate Preparation Products And Raw materials
Raw materialsSulfuric acid-->2-Nitrophenol-->2-Aminophenol
Copper quinolate 8-Hydroxyquinoline Neomycin sulfate sulfate Sodium sulfate D-Glucosamine sulfate 8-HYDROXYQUINOLINE POTASSIUM SULFATE SODIUM SULFATE n-Dodecyl alcohol, sulfated Atropine sulfate Colistin sulfate Aluminum sulfate GOLD COAST SOLUTION NO 1 SULFATE STANDARD Magnesium sulfate 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Ammonium sulfate Magnesium sulfate heptahydrate

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