MG149

MG149 Basic information
Product Name:MG149
Synonyms:MG 149;2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-benzoic acid;MG 149 Benzoic acid, 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-;MG149 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-Benzoic acid;2-(4-heptylphenethyl)-6-hydroxybenzoic acid;CS-1878;CHEMBL1215739;CHEMBL1215739; MG 149; MG-149
CAS:1243583-85-8
MF:C22H28O3
MW:340.46
EINECS:604-604-1
Product Categories:Inhibitors
Mol File:1243583-85-8.mol
MG149 Structure
MG149 Chemical Properties
Boiling point 477.8±33.0 °C(Predicted)
density 1.100±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥114 mg/mL in DMSO; ≥30.5 mg/mL in EtOH; insoluble in H2O
form Powder
pka3.06±0.30(Predicted)
Safety Information
MSDS Information
MG149 Usage And Synthesis
Biological Activitymg 149 is an inhibitor of histone acetyltransferases (hat) with ic50 values of 74μm and 47μm for tip60 and mof, respectively [1].mg 149 is an anacardic acid derivative. it shows selective inhibition towards the myst type of hats: tip60 and mof with ic50 values of 74μm and 47μm, respectively. the docking study shows that the inhibition of tip60 by mg 149 is competitive with respect to ac-coa in the ac-coa binding pocket of tip60. mg 149 also inhibits the activity of hat in nuclear extracts from hela cells using biotinylated histone h3 or histone h4 peptides as substrates. it is found to be more potent for histone h3 compared to histone h4. additionally, dna microarrays demonstrate that mg149 inhibits p53 and nf-kb pathways as well as a very limited number of other pathways [1, 2].
references[1] ghizzoni m, wu j, gao t, haisma hj, dekker fj, george zheng y. 6-alkylsalicylates are selective tip60 inhibitors and target the acetyl-coa binding site. eur j med chem. 2012 jan;47(1):337-44.
[2] dekker fj, van den bosch t, martin ni. small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases. drug discov today. 2014 may;19(5):654-60.
MG149 Preparation Products And Raw materials
Raw materials4H-1,3-Benzodioxin-4-one, 5-[2-(4-heptylphenyl)ethyl]-2,2-dimethyl-
BI 2536 Vorinostat ABT 737 VE-821 Panobinostat C 646

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