[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Basic information
Product Name:[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
Synonyms:[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone;KW 2449;(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone;KW2449(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanonehydrochloride;KW-2449;KW 2449; KW2449;[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone;KW-2449 100MG;{4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone
CAS:1000669-72-6
MF:C20H20N4O
MW:332.4
EINECS:
Product Categories:Inhibitors;Inhibitor
Mol File:1000669-72-6.mol
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Structure
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Chemical Properties
Boiling point 604.1±55.0 °C(Predicted)
density 1.28
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
pka13.76±0.40(Predicted)
form solid
color Pale yellow
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
MSDS Information
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Usage And Synthesis
DescriptionKW-2449 is a potent multikinase inhibitor (IC50’s: FLT3 = 7 nM, FGFR1 = 36 nM, Abl = 14 nM, Abl-T315 = 4 nM) with anti-leukemic effects.1,2,3
DefinitionChEBI: [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone is a member of indazoles.
targetFLT3
ReferencesShiotsu et al. (2007) KW-2449, a Novel Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1, and Aurora, Suppresses the Growth of AML Both In Vitro and In Vivo; Blood; 110 1832 Shiotsu et al. (2009) KW-2449, a Novel Multi-Kinase Inhibitor, suppresses the growth of leukemia cells with FLTY3 mutations or T315l-mutated BCR/ABL translocation; Blood; 114 1607 Pratz et al. (2009) A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response; Blood; 113 3938
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Preparation Products And Raw materials
SU 4312 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride Ibrutinib (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT Veliparib (+)-Camptothecin Entinostat FLUSULFAMIDE Dasatinib MK-2206 2HCl TYRPHOSTIN AG 1296

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.