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| | Menlaquinone 7 Basic information |
| Product Name: | Menlaquinone 7 | | Synonyms: | MENAQUINONE-7;(all-E)-2-(3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione;Menaquinone K7;Vitamin K2(35);Vitamin MK 7;Menlaquinone 7;MK-7;2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptenyl]-3-methyl-1,4-naphthalenedione | | CAS: | 2124-57-4 | | MF: | C46H64O2 | | MW: | 649 | | EINECS: | | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;APIs | | Mol File: | 2124-57-4.mol |  |
| | Menlaquinone 7 Chemical Properties |
| Melting point | 54 °C | | Boiling point | bp0.0002 200° (some dec) | | density | 0.961 | | storage temp. | -20°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Solid | | color | Pale Yellow to Yellow | | Stability: | Light and Temperature Sensitive | | InChIKey | RAKQPZMEYJZGPI-LJWNYQGCSA-N | | SMILES | C1(=O)C2=C(C=CC=C2)C(=O)C(C)=C1C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(/C)\C | | LogP | 14.451 (est) |
| | Menlaquinone 7 Usage And Synthesis |
| Description | Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods. It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 μM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats. In vivo, MK-7 (100 μg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification. It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss. | | Chemical Properties | Light Yellow Crystalline Solid | | Uses | Vitamin (prothrombogenic) | | Uses | Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari
ety of physiological processes. Menaquinone 7 belongs to the class of K2-Vitamins homologs. Menaquinone 7 has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-prote
ins such as osteocalcin and matrix-Gla protein, which plays a crucial role in building and maintaining overall bone health. | | Uses | Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) can be used as a stable isotope internal standard for data interpretation in specific biological samples. | | Definition | ChEBI: A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation. | | General Description | Vitamin K2, also known as menaquinone, is a polyisoprenoid-substituted?napthoquinone. Menaquinone-7 (MK-7) is a subtype of vitamin K2. It is found in animals, soy protein, fermented products and is primarily produced by bacteria.
Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) is a deuterated vitamin K2 wherein C-5, C-6, C-7, C-8, and 2-methyl protons are replaced by deuterium. |
| | Menlaquinone 7 Preparation Products And Raw materials |
| Raw materials | Naphthalene, 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaen-1-yl]-1,4-dimethoxy-3-methyl- |
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