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| | QUINUCLIDINE Basic information |
| Product Name: | QUINUCLIDINE | | Synonyms: | 1,4-ethanopiperidine;1,4-ethylidinepiperidine;1-Azabicyclo[2.2.2]octan;4-Azabicyclo[2.2.2]octane;Cevimeline, Hydrochloride Salt ((+/-)-cis-2-Methylspiro[1,3-oxathiolane-5,3’;Chinuclidin;QUINUCLIDINE;1-AZABICYCLO[2.2.2]OCTANE | | CAS: | 100-76-5 | | MF: | C7H13N | | MW: | 111.18 | | EINECS: | 202-887-1 | | Product Categories: | | | Mol File: | 100-76-5.mol |  |
| | QUINUCLIDINE Chemical Properties |
| Melting point | 157-160 °C (lit.) | | Boiling point | 198.35°C (rough estimate) | | density | 0.8928 (rough estimate) | | vapor pressure | 1.5 mm Hg ( 20 °C) | | refractive index | 1.4500 (estimate) | | solubility | H2O: very slightly soluble | | pka | 10.87±0.33(Predicted) | | form | powder to crystal | | color | White to Light yellow | | Water Solubility | Soluble in alcohol, diethyl ether, water and organic solvents. | | Sensitive | Air Sensitive | | Merck | 14,8081 | | BRN | 103111 | | InChIKey | SBYHFKPVCBCYGV-UHFFFAOYSA-N | | CAS DataBase Reference | 100-76-5(CAS DataBase Reference) | | EPA Substance Registry System | 1-Azabicyclo[2.2.2]octane (100-76-5) |
| Hazard Codes | T | | Risk Statements | 24/25-38-41 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2811 6.1/PG 2 | | WGK Germany | 3 | | RTECS | CL5594625 | | F | 2-10 | | TSCA | Yes | | HS Code | 2933.39.9200 | | HazardClass | 8 | | PackingGroup | III |
| | QUINUCLIDINE Usage And Synthesis |
| Uses | Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. It is employed to prepare quinine and alkaloids. It finds application as a ligand, which is useful in the studies of OsO4-catalyzed dihydroxylation of olefins. It plays an important role in the formation of onium salts used testing of PAC-antagonist activity. | | Definition | ChEBI: Quinuclidine is a saturated organic heterobicyclic parent and a member of quinuclidines. | | Hazard | A poison by ingestion and skin contact.
Low toxicity by inhalation. A moderate skin and
severe eye irritant.
| | Purification Methods | Crystallise it from diethyl ether. The hydrochloride has m 364-365o(dec) (from EtOH or n-BuOH), and the picrate has m 225o (from aqueous EtOH). [Beilstein 20 H 144, 20 II 71, 20 III/IV 1966, 20/4 V 335.] |
| | QUINUCLIDINE Preparation Products And Raw materials |
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