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| | 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER Basic information |
| Product Name: | 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER | | Synonyms: | propanetetracarboxylicacidtetraethylester;1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER;TETRAETHYL PROPANE-1,1,2,3-TETRACARBOXYLATE;2,3-Bis(ethoxycarbonyl)pentanedioic acid diethyl ester;Propane-1,1,2,3-tetracarboxylic Acid Tetraethyl Ester;1,1,2,3-Propanetetracarboxylic acid, 1,1,2,3-tetraethyl ester;TetraethylPropane-1,1,2,3-tetracarboxylate> | | CAS: | 635-03-0 | | MF: | C15H24O8 | | MW: | 332.35 | | EINECS: | 211-222-4 | | Product Categories: | | | Mol File: | 635-03-0.mol |  |
| | 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER Chemical Properties |
| Boiling point | 389.48°C (rough estimate) | | density | 1.1184 | | refractive index | 1.4380-1.4420 | | form | clear liquid | | pka | 11.42±0.59(Predicted) | | color | Colorless to Almost colorless | | InChIKey | WGEVJRBJWMGTSI-UHFFFAOYSA-N |
| | 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER Usage And Synthesis |
| Uses | 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Synthesis | 
Condensation of diethylfumarate and diethylmalonate to propane-1,1,2,3 tetracarboxylate. Catalyst specifications: Catalytic entity: Ph(CH2)-N+(PhmSO3-)3 · EtO- (1 milieq of EtO-), additive:: Sodium meta silicate 1 gm, Support: Charcoal 5 gm, Group IIA metal salt: Barium hydroxide, Method of preparation: Deposition precipitation. Procedure: in a 100-ml flask fitted with an efficient reflux condenser, magnetic stirrer bar and dropping funnel was charged 5 gm of catalyst. With stirring 1.6 g (0.001 mol) diethylmalonate and 25 ml dry ethanol was added. Reaction mixture was warmed and 1.4 gm (0.0081 mol) diethyl fumarate was added. Mixture was refluxed for 8 hours. Reaction mixture was cooled and suspension was centrifuged to recover catalyst. Analysis of reaction liquid indicated 90 % conversion for diethylmalonate. Product was distilled under vacuum 8 mm at 180-190°C to obtain propane-1,1,2,3 tetracarboxylate 85% yield. Catalyst was recovered and washed with ethanol, diethyl ether and dried under vacuum. Catalyst was recycled to obtain equivalent activity. |
| | 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER Preparation Products And Raw materials |
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