Methyl bromoacetate

Methyl bromoacetate Basic information
Product Name:Methyl bromoacetate
Synonyms:Methyl broMoacetate, 99% 100GR;Methyl broMoacetate, 99% 25GR;Methyl BroMoacetate(Methyl 2-BroMoacetate;Methyl broMoacetate 97%;BroMine Methyl acetate;Methyl bromoacetate,99%;Aceticacid,bromo-,methylester;bromo-aceticacimethylester
CAS:96-32-2
MF:C3H5BrO2
MW:152.97
EINECS:202-499-2
Product Categories:Organics;C2 to C5;Carbonyl Compounds;Esters;500 Series Drinking Water Methods;BromoEPA;Chemical Class;Halogenated;Method 552;Building Blocks;C2 to C5;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
Mol File:96-32-2.mol
Methyl bromoacetate Structure
Methyl bromoacetate Chemical Properties
Melting point -50°C
Boiling point 51-52 °C/15 mmHg (lit.)
density 1.616 g/mL at 25 °C (lit.)
vapor pressure 18 hPa (50 °C)
refractive index n20/D 1.458(lit.)
Fp 145 °F
storage temp. Store below +30°C.
form Liquid
Specific Gravity1.416
color Clear colorless to slightly yellow
Water Solubility Miscible with methanol, ether and acetone. Slightly miscible with water
FreezingPoint <-50℃
BRN 506256
LogP0.71 at 25℃
CAS DataBase Reference96-32-2(CAS DataBase Reference)
NIST Chemistry ReferenceAcetic acid, bromo-, methyl ester(96-32-2)
EPA Substance Registry SystemAcetic acid, bromo-, methyl ester (96-32-2)
Safety Information
Hazard Codes T,Xi,F
Risk Statements 25-34-37-23/24/25-40-36/37/38-38
Safety Statements 26-36/37/39-45-28A-36-16
RIDADR UN 2643 6.1/PG 2
WGK Germany 3
RTECS AF6300000
19
TSCA Yes
HazardClass 6.1
PackingGroup II
HS Code 29159080
Hazardous Substances Data96-32-2(Hazardous Substances Data)
MSDS Information
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Methyl bromoacetate English
SigmaAldrich English
ACROS English
ALFA English
Methyl bromoacetate Usage And Synthesis
Chemical PropertiesColorless liquid
UsesMethyl bromoacetate is used in the synthesis of coumarins and cis-cyclopropanes. It reacts with the conjugate base of (methylmethoxycarbene)pentacarbonylchromium(0) to prepare alkylated carbene complexes. Further, it is used to make vitamins and pharmaceuticals.
UsesMethyl bromoacetate was used in the synthesis of novel coumarins. It was also employed in the synthesis of cis-cyclopropanes
ApplicationMethyl Bromoacetate is an organic building block that has been used as a reactant in the preparation of isoquinolinone indole acetic acid derivatives as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.
General DescriptionA colorless to straw-colored liquid with a sharp penetrating odor. Denser than water and soluble in water. Severly irritates skin and eyes. Toxic by ingestion and inhalation. Used to make vitamins and pharmaceuticals.
Air & Water ReactionsHighly flammable. Soluble in water.
Reactivity ProfileMethyl bromoacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
HazardVapor is strong irritant to eyes.
Health HazardTOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire HazardHIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Safety ProfilePoison by intravenous route. When heated to decomposition it emits toxic fumes of Br-. See also ESTERS.
Phenyl bromoacetate Methyl phenoxyacetate Methyl METHYL BROMOACETATE (67.2.6) Ethyl 2-(Chlorosulfonyl)acetate METHYL BROMOACETATE SOLUTION 100UG/ML IN T-BUTYLMETHYL ETHER 1ML METHYL BROMOACETATE-D2,METHYL BROMOACETATE-2,2-D2,METHYL BROMOACETATE-D2, 98 ATOM % D METHYL BROMOACETATE 1X1ML MTBE 1000UG& METHYL BROMOACETATE, [2-14C] METHYL BROMOACETATE SOLUTION 100UG/ML IN T-BUTYLMETHYL ETHER 5X1ML Methyl 3-oxovalerate METHYL ALPHA-BROMO-2-CHLOROPHENYLACETATE Methyl 2,2-dimethylphenylacetate METHYL BROMOACETATE, 1X1ML, MTBE 1000UG/ ML METHYL BROMOACETATE, [1-14C] METHYL BROMOACETATE-1-13C METHYL BROMOACETATE SOLUTION 100UG/ML IN T-BUTYLMETHYL ETHER 5ML METHYL Α-NAPHTHYLACETATE

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