Oxymetazoline hydrochloride

Oxymetazoline hydrochloride Basic information
Product Name:Oxymetazoline hydrochloride
Synonyms:2-(4-t-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoliniumchloride;2,6-dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazolinehydrochlori;6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenohydrochloride;6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenolhydrochloride;OXYMETAZOLINE HCL;OXYMETAZOLINE HYDROCHLORIDE;3-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL-6-(1,1-DIMETHYLETHYL)-2,4-DIMETHYLPHENOL, HCL;3-[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL]-6-(1,1-DIMETHYLETHYL)-2,4-DIMETHYL-PHENOL HYDROCHLORIDE
CAS:2315-02-8
MF:C16H25ClN2O
MW:296.84
EINECS:219-015-0
Product Categories:PAVABID;Adrenoceptor;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API
Mol File:2315-02-8.mol
Oxymetazoline hydrochloride Structure
Oxymetazoline hydrochloride Chemical Properties
Melting point approximate 300℃ (dec.)
storage temp. Store at RT
solubility H2O: soluble
form solid
color white
PHpH (50g/L, 25℃) : 4.0~6.5
Water Solubility Soluble to 50 mM in water
Stability:Toxic
CAS DataBase Reference2315-02-8(CAS DataBase Reference)
Safety Information
Hazard Codes T+
Risk Statements 28
Safety Statements 22-28-36/37/39-45
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS SK1225000
HazardClass 6.1(a)
PackingGroup II
HS Code 2933290000
ToxicityLD50 orally in mice: 10 mg/kg (Hotovy)
MSDS Information
ProviderLanguage
SigmaAldrich English
Oxymetazoline hydrochloride Usage And Synthesis
Chemical PropertiesOff-White Solid
OriginatorNasivin,Merck,W. Germany ,1961
Usesmuscle relaxant (smooth), cerebral vasodilator
UsesVasoconstrictor, used as a nasal decongestant. An ingredient of Drixin.
UsesOxymetazoline hydrochloride is an α1-AR and α2-AR adrenergic receptor agonist and used as Vasoconstrictor, a nasal decongestant.
DefinitionChEBI: A hydrochloride salt resulting from the reaction of equimolar quantities of oxymetazoline and hydrogen chloride. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used to relieve nasal con estion.
Manufacturing Process10 grams 2,6-dimethyl-3-hydroxy-4-tertiary butylbenzylcyanide (produced by chloromethylation of 2,4-dimethyl-6-tertiary butyl-phenol with formaldehyde and HCl and conversion of the substituted benzyl chloride with NaCN; crystals, from alcohol, melting at 135° to 137°C) and 10.7 grams ethylenediaminemono-p-toluenesulfonate are heated in an oil bath to approximately 235°C for 1? hours, whereby ammonia is evolved. The free base is obtained from the p-toluene-sulfonic acid imidazoline salt which is difficultly soluble in water, by conversion with 50 cc of a 10% NaOH solution. Said base is recrystallized from benzene, and 7.5 grams (62% of the theoretical yield) 2-(2',6'-dimethyl3'-hydroxy-4'-tertiary butylbenzyl)-2-imidazoline, MP 180° to 182°C, are obtained.
By dissolving the free base in an ethyl alcohol solution of hydrochloric acid and adding ether, the hydrochloride can be produced in the usual manner. Said hydrochloride melts, when recrystallized from alcoholic ether, at 300° to 303°C and is decomposed
Brand nameOcuclear (Schering-Plough); Visine (Pfizer).
Therapeutic FunctionNasal decongestant
Biological ActivityPartial α 2A adrenoceptor agonist and α 1A agonist. Agonist/antagonist activity at 5-HT receptors.
Oxymetazoline hydrochloride Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Hydrochloric acid-->Sodium cyanide-->Formaldehyde-->Ethylenediamine-->p-Toluenesulfonic acid
Preparation ProductsOxymetazoline
Oxymetazoline 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Dacthal Benzyl chloride N,N-Dimethylformamide Topotecan hydrochloride tert-Butyldimethylsilyl chloride Sibutramine hydrochloride Tramadol hydrochloride ETHANE propionamidine hydrochloride 6-tert-Butyl-m-cresol 1-AdaMantanethylaMine Oxymetazoline hydrochloride Dimethyl sulfoxide Dimethyl carbonate tert-Butylhydrazine hydrochloride Dimethyl sulfate

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.