Calcium citrate

Calcium citrate Basic information
Description References
Product Name:Calcium citrate
Synonyms:1,2,3-Propanetricarboxylicacid,2-hydroxy-,calciumsalt(2:3);2,3-propanetricarboxylicacid,2-hydroxy-calciumsalt(2:3);acicontral;citricacid,calciumsalt(2:3);Calsium citrate;supply good quality calcium citrate;citrical;tribasiccalciumcitrate
CAS:813-94-5
MF:C12H10Ca3O14
MW:498.43
EINECS:212-391-7
Product Categories:Food additive and acidulant
Mol File:813-94-5.mol
Calcium citrate Structure
Calcium citrate Chemical Properties
solubility 0.1 M HCl: 0.01 M at 20 °C, clear, colorless
Odorat 100.00?%. odorless
Stability:Stable. Incompatible with strong oxidizing agents.
LogP-1.721 (est)
CAS DataBase Reference813-94-5(CAS DataBase Reference)
EPA Substance Registry SystemTricalcium citrate (813-94-5)
Safety Information
WGK Germany 1
Hazardous Substances Data813-94-5(Hazardous Substances Data)
MSDS Information
Calcium citrate Usage And Synthesis
DescriptionCalcium citrate, a naturally occurring chemical in most plants and animals, is the calcium salt derived from citric acid. Calcium citrate is present in foods which have naturally occurring citric acid. Calcium citrate is used as a calcium supplement and may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). Calcium citrate may be chemopreventive for colon and other cancers. Calcium citrate is used as an ingredient in dietary supplements, and as a nutrient, sequestrant, buffer, antioxidant, firming agent, acidity regulator (in jams and jellies, soft drinks and wines), as a raising agent and an emulsifying salt. It is also used to improve the baking properties of flours and as a stabilizer.
References
  1. https://www.cancer.gov
  2. https://www.drugs.com
  3. https://www.webmd.com
  4. https://www.livestrong.com
  5. https://www.ams.usda.gov
DescriptionCalcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions. Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 21% of calcium citrate by weight.
Chemical Propertieswhite powder or white to colourless crystals
Production MethodsCalcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid.
DefinitionChEBI: Calcium citrate is an organic calcium salt composed of calcium cations and citrate anions in a 3:2 ratio. It has a role as a nutraceutical, a food additive, a food preservative and a flavouring agent. It contains a citrate(3-).
Flammability and ExplosibilityNonflammable
Pharmaceutical ApplicationsCalcium citrate is more easily absorbed (bioavailability is 2.5 times higher than calcium carbonate); it is easier to digest and less likely to cause constipation and gas than calcium carbonate. Calcium citrate can be taken without food and is more easily absorbed than calcium carbonate on an empty stomach. It is also believed that it contributes less to the formation of kidney stones. Calcium citrate consists of around 24% Ca2+, which means that 1000 mg calcium citrate contains around 240 mg Ca2+. The lower Ca2+ content together with the higher price makes it a more expensive treatment option compared to calcium carbonate, but its slightly different application field can justify this.
Biological ActivityIn many individuals, bioavailability of calcium citrate is found to be equal to that of the cheaper calcium carbonate.However, alterations to the digestive tract may change how calcium is digested and absorbed. Unlike calcium carbonate, which is basic and neutralizes stomach acid, calcium citrate has no effect on stomach acid. Individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid should choose calcium citrate over calcium carbonate for supplementation. According to recent research into calcium absorption after gastric bypass surgery , calcium citrate may have improved bioavailability over calcium carbonate in Rouxen- Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery. This is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals.
Calcium citrate Preparation Products And Raw materials
Raw materialsCalcium carbonate-->Citric acid-->Calcium chloride hexahydrate-->Citric acid monohydrate
Piperazine citrate Sodium citrate CITRATE Clomiphene Citrate Calcium carbonate Calcium chloride Calcium carbide Calcium citrate malate Calcium Propionate Zinc citrate Mosapride citrate Calcium citrate CHLOROPHOSPHONAZO III Sildenafil citrate 2-[5-(4-Chlorophenyl)pentyl]oxirane-2-carboxylic acid OXELADIN CITRATE Citric acid Calcium citrate,Calcium citrate, (L-A148),Calcium citrate, monobasic

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