Disodium edetate dihydrate

Disodium edetate dihydrate Basic information
Product Name:Disodium edetate dihydrate
Synonyms:Disodium Dihydrogen Ethylenediaminetetraacetate Dihydrate [for Biochemical Research];Edetate DisodiuM, Dihydrate, Crystal, USP;DisodiuM Dihydrogen EthylenediaMinetetraacetate ;EthylenediaMinetetraacetic acid, disodiuM salt dihydrate, for analysis, 99+% 100GR;EthylenediaMinetetraacetic acid, disodiuM salt dihydrate, for analysis, 99+% 1KG;EthylenediaMinetetraacetic acid, disodiuM salt dihydrate, for analysis, 99+% 500GR;Ethylenediaminetetraacetic Acid Disodium Salt EDTA 2Na ETA;EthylenediaMinetetraacetic acid disodiuM solution
CAS:6381-92-6
MF:C10H19N2NaO9
MW:334.26
EINECS:613-386-6
Product Categories:Cosmetic or Industrial Grade;organic amine;Food Additives;reagent;Organic Chemicals;Analytical Chemistry;Chelating Reagents;Complexones;EDTA Analogs
Mol File:6381-92-6.mol
Disodium edetate dihydrate Structure
Disodium edetate dihydrate Chemical Properties
Melting point 250 °C (dec.)(lit.)
Boiling point >100 °C
density 1.01 g/mL at 25 °C
refractive index n20/D 1.363
FEMA 4520 | ETHYLENEDIAMINETETRAACETIC ACID DISODIUM SALT
Fp >100℃
storage temp. room temp
solubility 3  M NaOH: 100 mg/mL
pkapK1:1.99;pK2:2.67;pK3:6.16;pK4:10.26 (25°C)
form crystalline
color ≤5 (0.5 M)(APHA)
OdorOdorless
PH Range4 - 5 at 10 g/l at 23 °C
PH4.0-5.5 (25℃, 0.1M in H2O)
Water Solubility soluble
λmaxλ: 260 nm Amax: 0.145
λ: 280 nm Amax: 0.025
BRN 3900609
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyQCDUWWPHAVXXQS-UHFFFAOYSA-L
CAS DataBase Reference6381-92-6(CAS DataBase Reference)
EPA Substance Registry SystemEthylenediaminetetraacetic acid disodium salt dihydrate (6381-92-6)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36-52/53-36/38-36/37/38-22
Safety Statements 26-61-37/39-36/37/39-36
WGK Germany 2
RTECS AH4025000
3
TSCA Yes
HS Code 29224995
ToxicityLD50 orally in Rabbit: > 2000 mg/kg
MSDS Information
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Disodium edetate dihydrate English
SigmaAldrich English
ACROS English
ALFA English
Disodium edetate dihydrate Usage And Synthesis
Chemical PropertiesWhite or almost white, crystalline powder.
UsesChelating agent; sequestering agent
UsesEthylenediaminetetraacetic acid disodium salt dihydrate is used as a chelator of divalent cations. It inhibits enzymes such as metalloproteases that require divalent cations for activity. It is also used in chelation therapy. It acts as a sequestering agent in shampoos, cleaners and other personal care products and serves as an anticoagulant for blood samples.
UsesEthylenediamine tetraacetic acid disodium dihydrate is used as chelating agent for metals and as pharmaceutic aid (chelating agent); as preservative in cosmetic products; anticoagulant.
DefinitionChEBI: A hydrate that is the dihydrate form of EDTA disodium salt.
General DescriptionEthylenediaminetetraacetic acid disodium salt dehydrate is designated as Molecular Biology grade and is suitable for molecular biology applications. It has been analyzed for the presence of nucleases and proteases.
Biochem/physiol ActionsZinc-dependent metalloproteinases, as well as other proteases that are stabilized by calcium, can be effectively inhibited by chelation of divalent metal ions with EDTA. Other chelators such as EGTA, specific for calcium, and 1,10-phenanthroline, highly specific for zinc, can be used to target these two different types of proteases.
Purification MethodsAnalytical reagent grade material can be used as primary standard after drying at 80o. Commercial grade material can be purified by crystallisation from water or by preparing a 10% aqueous solution at room temperature, then adding ethanol slowly until a slight permanent precipitate is formed, filtering, and adding an equal volume of ethanol. The precipitate is filtered off onto a sintered-glass funnel, is washed with acetone, followed by diethyl ether, and dried in air overnight to give the dihydrate. Drying at 80o for at least 24hours converts it to the anhydrous form. [Beilstein 4 IV 2451.]
IDRANAL IV R. G.,idranal iv IDRANAL-A-SOLUTION IDRANAL(R) IDRANAL(R) C IDRANAL III R. G., REAG. PH. EUR. IDRANAL II-COPPER SOLUTION ETHYLENEDIAMINETETRAACETIC ACID DISODIUM SALT, 0.115N (0.0575M) STANDARDIZED SOLUTION ETHYLENEDIAMINETETRAACETIC ACID CALCIUM DISODIUM SALT HYDRATE Ethyl 2-(Chlorosulfonyl)acetate Ascoric Acid DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) IDRANAL-C-SOLUTION IDRANAL B FIXANAL SOD EDTA IDRANAL III solution 0.1 mol/L COBALT ETHYLENE DIAMINE CHLORIDE IDRANAL(R) II-MAGNESIUM,IDRANAL II-MAGNESIUM R. G.,idranal ii-magnesium FOROXYMITHINE Edta Disodium Salt Dihydrate Ethylenediaminetetraacetic Acid Disodium Salt Dihydrate

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