epothilone F

epothilone F Basic information
Product Name:epothilone F
Synonyms:epothilone F;CS-1032;4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-3-[(1E)-2-[2-(hydroxymethyl)-4-thiazolyl]-1-methylethenyl]-8,8,10,12,16-pentamethyl-, (1S,3S,7S,10R,11S,12S,16R)-;Ixabepilone Impurity 8 (Epothilone F);(1S,3S(E),7S,10R,11S,12S,16R)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-1-methyl-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione;epothilone F USP/EP/BP
CAS:208518-52-9
MF:C27H41NO7S
MW:523.68
EINECS:
Product Categories:
Mol File:208518-52-9.mol
epothilone F Structure
epothilone F Chemical Properties
Boiling point 711.3±60.0 °C(Predicted)
density 1.179±0.06 g/cm3(Predicted)
pka13.15±0.10(Predicted)
Safety Information
MSDS Information
epothilone F Usage And Synthesis
UsesEpothilone F is a related compound of Epothilones, which are a novel class of antineoplastic agents with antitubulin activity. In addition, Epothilones utilize a similar mechanism of action to that of taxanes and are less susceptible to multidrug resistance caused by P-glycoprotein. Studies showed that Epothilones exhibit antitumor activity against human cancer cells that are taxane-resistant.
epothilone F Preparation Products And Raw materials
EPOA Epothilone D (1S,3S,7S,10R,11S,12S,16R)-3-[(1E)-2-[2-(Aminomethyl)-4-thiazolyl]-1-methylethenyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Erythromycin

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