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| | 8-Hydroxyquinaldine Basic information |
| | 8-Hydroxyquinaldine Chemical Properties |
| Melting point | 71-73 °C(lit.) | | Boiling point | 267 °C(lit.) | | density | 1.1202 (rough estimate) | | refractive index | 1.6070 (estimate) | | Fp | 139°C | | storage temp. | Store below +30°C. | | solubility | 0.4g/l | | form | Crystalline Powder | | pka | pK1:5.55(＋1);pK2:10.31(0) (25°C) | | color | Beige to brown | | PH | 7-8 (100g/l, H2O, 20℃)(slurry) | | Water Solubility | insoluble | | BRN | 119194 | | CAS DataBase Reference | 826-81-3(CAS DataBase Reference) | | NIST Chemistry Reference | 8-Quinolinol, 2-methyl-(826-81-3) | | EPA Substance Registry System | 8-Quinolinol, 2-methyl- (826-81-3) |
| Hazard Codes | N,Xi | | Risk Statements | 50/53-36/37/38 | | Safety Statements | 60-61-24/25-36-26 | | RIDADR | UN 3077 9/PG 3 | | WGK Germany | 2 | | RTECS | VC7920000 | | Hazard Note | Irritant | | TSCA | Yes | | HazardClass | 9 | | PackingGroup | III | | HS Code | 29334990 |
| | 8-Hydroxyquinaldine Usage And Synthesis |
| Chemical Properties | beige to brown crystalline powder. Soluble in hot alcohol, ether and benzene, insoluble in water. Can volatilize with water vapor and sublimate at 100℃. With phenol odor. | | Uses | 8-Hydroxyquinaldine is mainly used as metal ion extractant and metal ion determination, also used in the synthesis of dyes and pigments and the preparation of pharmaceutical intermediates. | | Preparation | 8-hydroxyquinaldine is obtained from the reaction of 2-aminophenol with crotonaldehyde. Mix 2-aminophenol and 2-Nitrophenol homogeneously and add hydrochloric acid. Add crotonaldehyde under stirring. Heat for 6h and leave overnight. Distill the reacted o-nitrophenol by water distillation, and add sodium hydroxide solution to the residual solution to make it weakly basic. Then add powdered carbonyls for saturation, and distill 8-Hydroxyquinaldine by water distillation, and then distill the crude product under reduced pressure and recrystallize it with ethanol to obtain 8-hydroxyquinaldine. | | Definition | ChEBI: 2-Methylquinolin-8-ol is a hydroxyquinoline. | | Synthesis Reference(s) | Tetrahedron, 52, p. 2937, 1996 DOI: 10.1016/0040-4020(95)01118-8 | | General Description | 2-Methyl-8-quinolinol is a methyl substituted quinolinol derivative that shows fungicidal property. It can also undergo complexation with transition metal complexes. | | Purification Methods | Crystallise the quinoline from EtOH or aqueous EtOH. Its solubility at 20o in H2O is 0.366g/L, and in CHCl3 it is 466g/L. It complexes with many metals. [Beilstein 21 H 106, 21 III/IV 2132.] |
| | 8-Hydroxyquinaldine Preparation Products And Raw materials |
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