PAC1

PAC1 Basic information
Product Name:PAC1
Synonyms:PAC1;4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide;PAC1,4-(PhenylMethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]Methylene]hydrazide;4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide;PAC-1,PAC1;Procaspase activating coMpound 1;(E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide;4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide PAC-1
CAS:315183-21-2
MF:C23H28N4O2
MW:392.49
EINECS:
Product Categories:Inhibitor;Inhibitors
Mol File:315183-21-2.mol
PAC1 Structure
PAC1 Chemical Properties
density 1.14
storage temp. Store at +4°C
solubility DMSO: ≥10mg/mL
form solid
pka8.82±0.40(Predicted)
color white
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months.
Safety Information
Hazard Codes Xn,N
Risk Statements 22-36/37/38-50/53
Safety Statements 26-36/37-60-61
RIDADR UN 3077
WGK Germany 3
HS Code 29335990
MSDS Information
PAC1 Usage And Synthesis
DescriptionPAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2?? Sensitizes cancer cells to various chemotherapeutic agents.3
UsesPAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.
Biological ActivityProcaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively).
storage+4°C
References1) Putt et al. (2006), Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy; Nat. Chem. Biol., 2 543 2) Peterson et al. (2009), PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition; J. Mol. Biol., 388 144 3) Bolham et al. (2016), Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with diverse Chemotherapeutics; ACS Cent. Sci., 2 545
PAC1 Preparation Products And Raw materials
Z-VAD-FMK Ruxolitinib 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Obatoclax mesilate AC-VDVAD-PNA Paclitaxel LY2109761 AC-LEU-GLU-THR-ASP-AFC AC-LEHD-AFC AC-DEVD-CHO AC-DEVD-AFC AC-VDVAD-CHO ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Z-YVAD-AFC Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Bortezomib AC-VEID-AMC PAC1

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